sulfonylurea


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Related to sulfonylurea: metformin, Biguanides, Sulfonylurea receptor

sulfonylurea

 [sul″fo-nil-u´re-ah]
any of a class of compounds that exert hypoglycemic activity by stimulating the islet tissue to secrete insulin; used to control hyperglycemia in patients with type 2 diabetes mellitus who cannot be treated solely by diet and exercise. The class includes the oral hypoglycemic agentsacetohexamide, chlorpropamide, glipizide, tolazamide, and tolbutamide.

sulfonylurea

(sŭl′fə-nĭl-yo͝o-rē′ə)
n.
Any of a group of hypoglycemic drugs, such as glyburide, that act on the beta cells of the pancreas to increase the secretion of insulin and are used in the treatment of type 2 diabetes.
References in periodicals archive ?
When controlling for other variables, the researchers found that metformin use was associated with a significantly lower risk for dementia compared with sulfonylurea use in African-American patients (hazard ratio [HR], 0.73; 95 percent confidence interval [CI], 0.6 to 0.89) but not among white patients (HR, 0.96; 95 percent CI, 0.9 to 1.03).
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin.
Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism.
Sulfonylureas maintain KATP channels in the closed position by binding to the regulatory sulfonylurea receptor and promoting insulin secretion.
Using these data, enrollees were matched by propensity score into 10,089 pairs consisting of a DPP-4 inhibitor user and a sulfonylurea user.
Weight gain is a concern with the use of sulfonylureas (especially when used in combination with insulin or higher-carbohydrate diets), as are hypersensitivity reactions, especially when a past reaction to a sulfonamide has been severe.
The evidence from this systematic review supports current type 2 diabetes guidelines that recommend metformin as the first-line agent to treat adults, based on its beneficial effects on hemoglobin [A.sub.lc], weight, and cardiovascular mortality versus sulfonylureas, as well as its relative safety profile, Dr.
The evidence from this systematic review supports current type 2 diabetes guidelines that recommend metformin as the first-line agent to treat adults, based on its beneficial effects on hemoglobin Alc level, weight, and cardiovascular mortality, versus sulfonylureas, as well as its relative safety profile, Dr.
Of these, 40,736 had received metformin in combination with a sulfonylurea and 12,024 had received a combination of metformin and a DPP-4 inhibitor and were studied further.
SAFES also came out with smart use of sulfonylureas while Dhaka Declaration has highlighted the management of Gestational Diabetes Mellitus to get better outcome.
After adjusting for a number of factors, the researchers found that the metformin-insulin combination was associated with a higher risk of a composite of heart attack, stroke, or death from any cause, compared to the use of metformin plus a sulfonylurea. Combined rates of heart attack and stroke, as well as fatal and non-fatal cardiovascular events, were similar between the two study groups, the researchers reported.
While 2,198 patients (24.5 percent) prescribed metformin required a second oral medication, 37.1 percent of patients prescribed a sulfonylurea, 39.6 percent prescribed a thiazolidinedione and 36.2 percent prescribed a DPP-4 inhibitor did.