sulfonylurea


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Related to sulfonylurea: metformin, Biguanides, Sulfonylurea receptor

sulfonylurea

 [sul″fo-nil-u´re-ah]
any of a class of compounds that exert hypoglycemic activity by stimulating the islet tissue to secrete insulin; used to control hyperglycemia in patients with type 2 diabetes mellitus who cannot be treated solely by diet and exercise. The class includes the oral hypoglycemic agentsacetohexamide, chlorpropamide, glipizide, tolazamide, and tolbutamide.

sulfonylurea

/sul·fo·nyl·urea/ (sul″fŏ-nil-u-re´ah) any of a class of compounds that exert hypoglycemic activity by stimulating the islet tissue to secrete insulin; used to control hyperglycemia in patients with type 2 diabetes mellitus who cannot be treated solely by diet and exercise.

sulfonylurea

(sŭl′fə-nĭl-yo͝o-rē′ə)
n.
Any of a group of hypoglycemic drugs, such as glyburide, that act on the beta cells of the pancreas to increase the secretion of insulin and are used in the treatment of type 2 diabetes.

sulfonylurea

[sul′fənilyoo͡r′ē·ə]
an oral antidiabetic agent that stimulates the pancreatic production of insulin. Hypersensitivity to sulfonamides is a contraindication for using such agents, and ethanol consumption is incompatible with all sulfonylureas. These agents cross the placenta, and their use has been associated with a higher incidence of birth defects, making insulin the preferred drug in treating diabetes in pregnancy. Aspirin or other salicylates taken with any sulfonylurea may intensify the hypoglycemic effect.

sulfonylurea

a class of chemical compounds that includes the oral hypoglycemic agents acetohexamide, chlorpropamide, tolazamide and tolbutamide.
References in periodicals archive ?
While metformin should be the first line choice for oral stage management of diabetes, often physicians opt to start treating patients with sulfonylurea monotherapy first," said Dr.
The study, funded by Merck Sharpe & Dohme, examined records from the GE Centricity Electronic Medical Records database for patients who received either sulfonylurea or metformin as their first diabetes drug during 2003-2007, remained on the drug for at least 90 days, and had no CVD events recorded in the year prior to the prescription, reported Dr.
Among those patients who had been using sulfonylureas for the previous 12 months, significantly more of them reported having hypoglycemia during the past month than did those who did not receive sulfonylureas (28% vs.
A higher incidence of hypoglycemia in the linagliptin group compared with the placebo group was seen in the linagliptin patients who were taking both metformin and a sulfonylurea.
BYETTA is an add-on therapy for people currently using metformin, a sulfonylurea, or a thiazolidinedione.
It included a total of 4,447 patients with type 2 diabetes whose glucose levels were inadequately controlled with either sulfonylurea or metformin alone.
The study findings demonstrate that treatment with Avandia resulted in significantly lower total medical costs for the patient over time, when compared to sulfonylurea therapy.
If the combination of lifestyle, metformin, and a sulfonylurea (or basal insulin) is ineffective in reaching glycemic targets, step 3 treatment, consisting of multiple injections of a short- or rapid-acting insulin with meals, is recommended.
If a sulfonylurea must be used, glipizide should be chosen, because it has a shorter half-life.
Subjects were treated with metformin, sulfonylurea drugs, insulin, metformin plus sulfonylureas, or metformin and insulin for no less than 180 days.