sulfonylurea


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Related to sulfonylurea: metformin, Biguanides, Sulfonylurea receptor

sulfonylurea

 [sul″fo-nil-u´re-ah]
any of a class of compounds that exert hypoglycemic activity by stimulating the islet tissue to secrete insulin; used to control hyperglycemia in patients with type 2 diabetes mellitus who cannot be treated solely by diet and exercise. The class includes the oral hypoglycemic agentsacetohexamide, chlorpropamide, glipizide, tolazamide, and tolbutamide.

sulfonylurea

/sul·fo·nyl·urea/ (sul″fŏ-nil-u-re´ah) any of a class of compounds that exert hypoglycemic activity by stimulating the islet tissue to secrete insulin; used to control hyperglycemia in patients with type 2 diabetes mellitus who cannot be treated solely by diet and exercise.

sulfonylurea

(sŭl′fə-nĭl-yo͝o-rē′ə)
n.
Any of a group of hypoglycemic drugs, such as glyburide, that act on the beta cells of the pancreas to increase the secretion of insulin and are used in the treatment of type 2 diabetes.

sulfonylurea

[sul′fənilyoo͡r′ē·ə]
an oral antidiabetic agent that stimulates the pancreatic production of insulin. Hypersensitivity to sulfonamides is a contraindication for using such agents, and ethanol consumption is incompatible with all sulfonylureas. These agents cross the placenta, and their use has been associated with a higher incidence of birth defects, making insulin the preferred drug in treating diabetes in pregnancy. Aspirin or other salicylates taken with any sulfonylurea may intensify the hypoglycemic effect.

sulfonylurea

a class of chemical compounds that includes the oral hypoglycemic agents acetohexamide, chlorpropamide, tolazamide and tolbutamide.
References in periodicals archive ?
The evidence from this systematic review supports current type 2 diabetes guidelines that recommend metformin as the first-line agent to treat adults, based on its beneficial effects on hemoglobin Alc level, weight, and cardiovascular mortality, versus sulfonylureas, as well as its relative safety profile, Dr.
The retrospective cohort database study included more than 35,000 individuals, of whom 26,883 received no antihyperglycemic treatment or treatment with an antihyperglycemic agent other than a sulfonylurea or metformin between January 2010 and December 2011, leaving 7,874 who were given metformin monotherapy and 904 given sulfonylurea monotherapy.
Oral alternatives to metformin included the sulfonylureas, pioglitazone, alpha-glucosidase inhibitors and gliptins.
Using a sulfonylurea appeared to be associated with an increased risk of cardiovascular events.
Soon thereafter, 1-butyl-3-sulfonylurea (carbutamide) became the first clinically useful sulfonylurea for the treatment of diabetes (2).
They found that patients treated with the TZD drugs pioglitazone (Actos) or rosiglitzaone (Avandia) for five or more years had a two-to-three-fold increase in risk of developing bladder cancer when compared to those who took sulfonylurea drugs.
Researchers evaluated "data from nearly 24,000 patients with type 2 diabetes, average age 62, who were treated with one of three drugs called sulfonylureas (glipizide, glyburide, and glimepiride) or with another type of drug called metformin.
10] The conventional approach in our clinic has been to start the treatment with a single well known second generation sulfonylurea drug (for example glipizide).
The first-generation sulfonylureas currently available are chlorpropamide (Di-abinese), tolazamide (Tolinase), and tolbutamide (Orinase).
Pioglitazone (Actos) and rosiglitazone (Avandia), both TZDs, are approved for use in combination with metformin, sulfonylureas, glinides and insulin.
TABLE 1: Anti-diabetic Drug Utilization (Individual\Combination) Anti-diabetic Mono- Combination Total drugs Therapy Sulfonylurea 11 119 130 (65%) Biguanide 7 123 130 (65%) Thiazolidinediones 13 43 56 (28%) Acarbose 5 1 6 (3%) Insulin 31 -- 31 (15.