sulfonamide


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Related to sulfonamide: sulfanilamide, Sulfonamide drugs

sulfonamide

 [sul-fon´ah-mīd]
1. a compound containing the -SO2NH2 group.
2. any of a group of structurally related antibiotics that competitively inhibit folic acid synthesis in microorganisms and formerly were bacteriostatic against a wide variety of gram-positive and gram-negative bacteria and some protozoa. Because many microbes are now resistant, sulfonamides have largely been supplanted by more effective and less toxic antibiotics. Called also sulfa drug.

sulfonamide

/sul·fon·amide/ (sul-fon´ah-mīd) a compound containing the sbondSO2NH2 group. The sulfonamides, or sulfa drugs, are derivatives of sulfanilamide, competitively inhibit folic acid synthesis in microorganisms, and formerly were bacteriostatic against a wide variety of bacteria and some protozoa. Because many microbes are now resistant, sulfonamides have largely been supplanted by more effective and less toxic antibiotics.

sulfonamide

(sŭl-fŏn′ə-mīd′, -mĭd)
n.
1. Any of a group of organic sulfur compounds containing the radical SO2NH2 and including the sulfa drugs.

sulfonamide

[səlfon′əmīd]
originally one of a large group of synthetic bacteriostatic drugs that are effective in treating infections caused by many gram-negative and gram-positive microorganisms. They are bacteriostatic rather than bactericidal. Some sulfonamides are short-acting, some are intermediate-acting, and some are long-acting, depending on the speed with which they are excreted. They are used in treating many urinary tract infections. A variety of other types of drugs have since been developed that are sulfonamide derivatives, including thiazide diuretics and some of the oral hypoglycemics. Some people are hypersensitive to the sulfonamides. Sulfonamides are given with caution to people who have impaired liver or kidney function, and they are not given in the last trimester of pregnancy or to young infants, because mental retardation sometimes can result. Hemolytic anemia; agranulocytosis; thrombocytopenia; or aplastic anemia, drug fever, and jaundice may occur, particularly with long-acting sulfonamides given for more than 10 days. Most sulfonamides are given orally.

Sulfonamide

A sulfa drug, one of a large group of drugs used to treat bacterial infections.
Mentioned in: Serum Sickness

sulfonamide 

Denotes a group of organic derivatives containing SO2 NH2. Example: sulfacetamide sodium.

sulfonamide (sulfon´əmīd),

n a derivative of sulfanilamide that is effective against microorganisms.

sulfonamide

1. any compound containing the −SO2NH2 group.
2. any of a group of drugs that are derivatives of sulfanilamide, which competitively inhibit folic acid synthesis in microorganisms, and are bacteriostatic against gram-positive cocci (streptococci and pneumococci), gram-negative cocci (meningococci and gonococci), gram-negative bacilli (Escherichia coli and shigellae), and a wide variety of other bacteria. Sulfonamides have been supplanted by more effective and less toxic antibiotics in most uses. Called also sulfa drugs.
References in periodicals archive ?
A recent study using the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey to examine >7,000 outpatient visits for UTIs among women aged [greater than or equal to] 18 years from 2002 to 2011 (6) found that 80% were prescribed antibiotics within 7 days of diagnosis; the most commonly prescribed medications were fluoroquinolones (39%), sulfonamides (22%), and nitrofurantoin (15%).
Sulfonamides are also very active in treatment of ophthalmic infections ulcerate colitis, scalds [10], rhemmatiod arthrist [11], male erectile dysfunction as the phosphodiesterase-5-inhibitor sildenafil [12] and obesity [13].
Brian Strom and colleagues conducted a retrospective cohort study using general practice research database, looking at risk of allergic reactions within 30 days of receipt of a sulfonamide nonantibiotic (N.
In this way, the co-solvent action may be related to the breaking of the ordered structure of water (hydrogen bonds) around the non-polar moieties of the drugs, which increases the solvation of these sulfonamides having maximum values in different co-solvent compositions according to each sulfonamide.
The new sulfonamide derivatives of sydnone were synthesized and evaluated their antibacterial activity.
1,2) The most common medications reported with TEN include sulfonamide antibiotics, aminopenicillins, anticonvulsants, oxicam nonsteroidal anti-inflammatory drugs, and allopurinol.
2002) recently described an extraction and cleanup procedure for the analysis of several sulfonamide compounds in shrimp.
Zonisamide, a sulfonamide drug, was approved in 2000 for use as add-on therapy for the treatment of partial seizures in adults with epilepsy.
Nelson Assigned: Dyneon LLC Keywords: Recycle component of a fluorinated elastomer, a fluoroaliphatic sulfonamide, free radical scavenger, a crosslinking agent
In this study, sulfonamide residue levels were monitored by a microbiological receptor assay (Charm II) and confirmed by high performance liquid chromatography (HPLC), in porcine muscles collected at federally-inspected packing plants of Northwestern Mexico.