sulfonamide


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to sulfonamide: sulfanilamide, Sulfonamide drugs

sulfonamide

 [sul-fon´ah-mīd]
1. a compound containing the -SO2NH2 group.
2. any of a group of structurally related antibiotics that competitively inhibit folic acid synthesis in microorganisms and formerly were bacteriostatic against a wide variety of gram-positive and gram-negative bacteria and some protozoa. Because many microbes are now resistant, sulfonamides have largely been supplanted by more effective and less toxic antibiotics. Called also sulfa drug.

sulfonamide

(sŭl-fŏn′ə-mīd′, -mĭd)
n.
1. Any of a group of organic sulfur compounds containing the radical SO2NH2 and including the sulfa drugs.

Sulfonamide

A sulfa drug, one of a large group of drugs used to treat bacterial infections.
Mentioned in: Serum Sickness

sulfonamide 

Denotes a group of organic derivatives containing SO2 NH2. Example: sulfacetamide sodium.
References in periodicals archive ?
Scozzafava, Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents, Med.
Sulfonamides: Sulfonamides are extensively used for prevention and control of bacterial diseases due to their bacteriostatic and bactericidal effects.
The proficient activity of first and second compound was the most likely due to occurrence of hydroxyl group at meta position of aniline ring and that of third compound was likely due to the presence of two alkyl groups on aniline ring along with ethyl group attached to nitrogen of sulfonamide.
([dagger]) For pregnant women in their first trimester, a 2011 Committee Opinion from the American College of Obstetricians and Gynecologists recommended that sulfonamides and nitrofurantoin may be prescribed only if other antimicrobial therapies are deemed clinically inappropriate (4).
Multiple reaction monitoring (MRM) was applied, and two product ions (for quantification and confirmation transition) were selected for each sulfonamide. The mass detector settings and gradient values for individual analytes are shown in Table 2.
The sulfonamide and trimethoprim identity was confirmed by obtaining the accurate mass of the protonated molecular ion, as well as by the consideration of fragment ions in order to obtain the identification points (IPs) according to Commission Decision 2002/657/EC [22] (Table 1).
[F.sub.LUMO], the hydrogen bond acceptor (HA), the hydrogen bond donor (HD), (logP), and R index are the descriptors dependent on the anticancer activity of a sulfonamide.
The aim of the present study was to use an eluent additive 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) to improve LC separation significantly with alternative selectivity in C18 stationary phase and enhance MS detection of fluoroquinolones (FQs) and sulfonamides (SAs) in small concentration levels to quantify them in food plant samples.
The model assumed that first-line empirical treatment of uUTIs would consist of one of the antibiotics currently reimbursed by the Ontario Drug Benefit Program (ODBP) [44] and recommended by recent guidelines [5, 13, 14] for the treatment uUTIs: sulfonamides (TMP/SMX DS 800 mg/160 mg, TMP 100 mg, or TMP 200 mg), fluoroquinolones (Cipro[R] XL[TM] 500 mg, ciprofloxacin 250 mg [generic], or norfloxacin 400 mg), or nitrofurantoins (MacroBID[R] 100 mg, nitrofurantoin 50 mg [generic], or nitrofurantoin 100 mg [generic]).
Pilar Tornero and colleagues used patch testing and control oral challenge in patients with previous fixed drug eruptions to trimethoprim-sulfamethoxazole or an unknown sulfonamide (Contact Dermatitis 2004;51:57-62).