sulfonamide


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Related to sulfonamide: sulfanilamide, Sulfonamide drugs

sulfonamide

 [sul-fon´ah-mīd]
1. a compound containing the -SO2NH2 group.
2. any of a group of structurally related antibiotics that competitively inhibit folic acid synthesis in microorganisms and formerly were bacteriostatic against a wide variety of gram-positive and gram-negative bacteria and some protozoa. Because many microbes are now resistant, sulfonamides have largely been supplanted by more effective and less toxic antibiotics. Called also sulfa drug.

sulfonamide

/sul·fon·amide/ (sul-fon´ah-mīd) a compound containing the sbondSO2NH2 group. The sulfonamides, or sulfa drugs, are derivatives of sulfanilamide, competitively inhibit folic acid synthesis in microorganisms, and formerly were bacteriostatic against a wide variety of bacteria and some protozoa. Because many microbes are now resistant, sulfonamides have largely been supplanted by more effective and less toxic antibiotics.

sulfonamide

(sŭl-fŏn′ə-mīd′, -mĭd)
n.
1. Any of a group of organic sulfur compounds containing the radical SO2NH2 and including the sulfa drugs.

sulfonamide

[səlfon′əmīd]
originally one of a large group of synthetic bacteriostatic drugs that are effective in treating infections caused by many gram-negative and gram-positive microorganisms. They are bacteriostatic rather than bactericidal. Some sulfonamides are short-acting, some are intermediate-acting, and some are long-acting, depending on the speed with which they are excreted. They are used in treating many urinary tract infections. A variety of other types of drugs have since been developed that are sulfonamide derivatives, including thiazide diuretics and some of the oral hypoglycemics. Some people are hypersensitive to the sulfonamides. Sulfonamides are given with caution to people who have impaired liver or kidney function, and they are not given in the last trimester of pregnancy or to young infants, because mental retardation sometimes can result. Hemolytic anemia; agranulocytosis; thrombocytopenia; or aplastic anemia, drug fever, and jaundice may occur, particularly with long-acting sulfonamides given for more than 10 days. Most sulfonamides are given orally.

Sulfonamide

A sulfa drug, one of a large group of drugs used to treat bacterial infections.
Mentioned in: Serum Sickness

sulfonamide 

Denotes a group of organic derivatives containing SO2 NH2. Example: sulfacetamide sodium.

sulfonamide (sulfon´əmīd),

n a derivative of sulfanilamide that is effective against microorganisms.

sulfonamide

1. any compound containing the −SO2NH2 group.
2. any of a group of drugs that are derivatives of sulfanilamide, which competitively inhibit folic acid synthesis in microorganisms, and are bacteriostatic against gram-positive cocci (streptococci and pneumococci), gram-negative cocci (meningococci and gonococci), gram-negative bacilli (Escherichia coli and shigellae), and a wide variety of other bacteria. Sulfonamides have been supplanted by more effective and less toxic antibiotics in most uses. Called also sulfa drugs.
References in periodicals archive ?
Pilar Tornero and colleagues used patch testing and control oral challenge in patients with previous fixed drug eruptions to trimethoprim-sulfame-thoxazole or an unknown sulfonamide (Contact Dermatitis 2004;51:5762).
Among 983 human isolates, resistance was observed most often to sulfonamide (19.
Studies of the DHPS locus have found mutations at positions 165 and 171, which confer potentially lower sensitivity to sulfonamides to mutant P.
Minocycline, penicillins, sulfonamides, ciprofloxacin, carbamazepine, and phenytoin are other major causative agents.
Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity.
The thiophthalimide (CTP) and sulfonamide classes of retarders differ from the organic acid types by their ability to retard scorch, or onset of vulcanization, without significantly affecting cure rate or performance properties.
These powders are made up of a variety of different combinations of an antibiotic (a quinolone, a sulfonamide, or chloramphenicol), an antifungal (clotrimazole or ampnotericin B), and a steroid (dexamethasone or hydrocortisone).
For instance, patients with allergy to sulfonamide antimicrobial agents may react to thiazide diuretics, oral hypoglycemic agents, or celecoxib.
The use of high amounts of veterinary drugs has led to the occurrence of tetracycline and sulfonamide residues in liquid manure and soil, as well as in surface water and, in the case of sulfonamides, also in groundwater (Berger et al.
The rubber stock was made of natural rubber, carbon black, silica and other additives such as bonding agent, salt additive, pine tar, sulfur and sulfonamide curing system.
SAN FRANCISCO -- Common drugs such as thiazide diuretics, glyburide, and celecoxib can be used safely by most patients who previously had a reaction to sulfonamide antibiotics, Dr.
In a study that he presented, only 2% of patients who were reported to have had an allergictype reaction to an antimicrobial sulfonamide such as trimethoprim-sulfamethoxazole had a reaction to another sulfa drug that was not an antimicrobial.