Like iron, copper, zinc, manganese, and cobalt, molybdenum (Mo) can be utilized as a stably bound, variably coordinated cofactor in proteins, in mammals, Mo is found in three different enzymes: aldehyde oxidoreductase (AOR), sulfite oxidase
(SOX), and xanthine oxidoreductase (XOR).
(SO) activity was determined by measuring sulphite disappearance using OHmediated discolouring of fuchsine according to Pachmayr's report .
First, there is conversion to sulfite, followed by rapid conversion of sulfite to harmless sulfate by the enzyme sulfite oxidase
.5 The function of sulfite oxidase
seems the limiting difficulty in cases of elevated urine sulfite.
In the case of sulfite sensitivity, there may be a deficiency of an enzyme called sulfite oxidase
, which breaks down sulfites with the help of the trace element molybdenum.
Sulfite is detoxified in the liver and lung to sulfate by sulfite oxidase
, a molybdenum-dependent mitochondrial enzyme (Cohen and Fridovich 1971); sulfite oxidase
deficiency is one of the most accepted causes of sulfite hypersensitivity and toxicity.
(AAT1) and Sulfite Oxidase
(SOX1) Genes from the Pathogenic
deficiency is so rare, only 16 cases have ever been found worldwide.
Called sulfite oxidase
, the enzyme converts the unwanted chemicals to other compounds that your body can either use of get rid of.
(15) It has been theorized that, by interfering with the activity of the detoxifying enzyme sulfite oxidase
(which requires molybdenum), a deficiency may increase the risk of developing non-specific symptoms due to toxicity from sulfur dioxide and dietary sulfites.
NM_001159.3), and sulfite oxidase
(SUOX; EC18.104.22.168, NCBI geneID: 6821, GenBank accession no.
In higher organisms, they fall into only two categories: xanthine dehydrogenases are involved in metabolic pathways; sulfite oxidases
catalyse a small but important set of reactions involved in brain development.