sulfite oxidase


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sul·fite ox·i·dase

[MIM*606887]
a liver oxidoreductase (hemoprotein) catalyzing the reaction of inorganic sulfite ion with O2 and water to produce sulfate ion and H2O2; a lower level of activity of this enzyme is observed in cases of molybdenum cofactor deficiency.

sul·fite ox·i·dase

(sŭl'fīt ok'si-dās)
A liver oxidoreductase (hemoprotein) catalyzing the reaction of inorganic sulfite ion with O2 and water to produce sulfate ion and H2O2; a lower activity of this enzyme is observed in cases of molybdenum cofactor deficiency.
Synonym(s): sulphite oxidase, sulphite oxidase.
References in periodicals archive ?
Like iron, copper, zinc, manganese, and cobalt, molybdenum (Mo) can be utilized as a stably bound, variably coordinated cofactor in proteins, in mammals, Mo is found in three different enzymes: aldehyde oxidoreductase (AOR), sulfite oxidase (SOX), and xanthine oxidoreductase (XOR).
In contrast to the more general Moco deficiency (MocoD) affecting all three enzymes, isolated sulfite oxidase deficiency (iSOD) cannot be treated yet.
Sulfite oxidase (SO) activity was determined by measuring sulphite disappearance using OHmediated discolouring of fuchsine according to Pachmayr's report [27].
First, there is conversion to sulfite, followed by rapid conversion of sulfite to harmless sulfate by the enzyme sulfite oxidase.5 The function of sulfite oxidase seems the limiting difficulty in cases of elevated urine sulfite.
In the case of sulfite sensitivity, there may be a deficiency of an enzyme called sulfite oxidase, which breaks down sulfites with the help of the trace element molybdenum.
Sulfite is detoxified in the liver and lung to sulfate by sulfite oxidase, a molybdenum-dependent mitochondrial enzyme (Cohen and Fridovich 1971); sulfite oxidase deficiency is one of the most accepted causes of sulfite hypersensitivity and toxicity.
(AAT1) and Sulfite Oxidase (SOX1) Genes from the Pathogenic
Sulfite oxidase deficiency is so rare, only 16 cases have ever been found worldwide.
Called sulfite oxidase, the enzyme converts the unwanted chemicals to other compounds that your body can either use of get rid of.
(15) It has been theorized that, by interfering with the activity of the detoxifying enzyme sulfite oxidase (which requires molybdenum), a deficiency may increase the risk of developing non-specific symptoms due to toxicity from sulfur dioxide and dietary sulfites.
NM_001159.3), and sulfite oxidase (SUOX; EC1.8.3.1, NCBI geneID: 6821, GenBank accession no.
In higher organisms, they fall into only two categories: xanthine dehydrogenases are involved in metabolic pathways; sulfite oxidases catalyse a small but important set of reactions involved in brain development.