sulfite oxidase


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sul·fite ox·i·dase

[MIM*606887]
a liver oxidoreductase (hemoprotein) catalyzing the reaction of inorganic sulfite ion with O2 and water to produce sulfate ion and H2O2; a lower level of activity of this enzyme is observed in cases of molybdenum cofactor deficiency.

sulfite oxidase

/sul·fite ox·i·dase/ (ok´sĭ-dās) an oxidoreductase that catalyzes the oxidation of sulfite to sulfate as well as the detoxification of sulfite and sulfur dioxide from exogenous sources. It is a mitochondrial hemoprotein containing molybdenum; deficiency results in progressive neurologic abnormalities, lens dislocation, and mental retardation.

sul·fite ox·i·dase

(sŭl'fīt ok'si-dās)
A liver oxidoreductase (hemoprotein) catalyzing the reaction of inorganic sulfite ion with O2 and water to produce sulfate ion and H2O2; a lower activity of this enzyme is observed in cases of molybdenum cofactor deficiency.
Synonym(s): sulphite oxidase, sulphite oxidase.
References in periodicals archive ?
Like iron, copper, zinc, manganese, and cobalt, molybdenum (Mo) can be utilized as a stably bound, variably coordinated cofactor in proteins, in mammals, Mo is found in three different enzymes: aldehyde oxidoreductase (AOR), sulfite oxidase (SOX), and xanthine oxidoreductase (XOR).
In contrast to the more general Moco deficiency (MocoD) affecting all three enzymes, isolated sulfite oxidase deficiency (iSOD) cannot be treated yet.
5 The function of sulfite oxidase seems the limiting difficulty in cases of elevated urine sulfite.
In the case of sulfite sensitivity, there may be a deficiency of an enzyme called sulfite oxidase, which breaks down sulfites with the help of the trace element molybdenum.
Sulfite is detoxified in the liver and lung to sulfate by sulfite oxidase, a molybdenum-dependent mitochondrial enzyme (Cohen and Fridovich 1971); sulfite oxidase deficiency is one of the most accepted causes of sulfite hypersensitivity and toxicity.
AAT1) and Sulfite Oxidase (SOX1) Genes from the Pathogenic
Sulfite oxidase deficiency is so rare, only 16 cases have ever been found worldwide.
Called sulfite oxidase, the enzyme converts the unwanted chemicals to other compounds that your body can either use of get rid of.
15) It has been theorized that, by interfering with the activity of the detoxifying enzyme sulfite oxidase (which requires molybdenum), a deficiency may increase the risk of developing non-specific symptoms due to toxicity from sulfur dioxide and dietary sulfites.
We also included discovery of polymorphic forms of genes that code for enzymes that are inhibited by tungsten: xanthine dehydrogenase, sulfite oxidase (SUOX gene), and aldehyde oxidase.
In higher organisms, they fall into only two categories: xanthine dehydrogenases are involved in metabolic pathways; sulfite oxidases catalyse a small but important set of reactions involved in brain development.