Gazi et al., "Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates
potassium channels," Circulation Research, vol.
(137) later proposed a mechanism through which [H.sub.2]S sulfurates (sulfhydrates
) cysteine residues of Keap1, which releases Nrf2 to the nucleus.
p66Shc at cysteine-59, which locates in the same C[H.sub.2] domain besides serine-36, disrupts the association between PK[C.sub.[beta]II] and p66Shc, inhibits PK[C.sub.[beta]II]-mediated p66Shc phosphorylation, and decreases mitochondria ROS generation finally.