MLD is caused by a mutation in the arylsulfatase-A (ARSA) gene that results in the accumulation of
sulfatides in the brain and other areas of the body, including the liver, the gall bladder, kidneys, and/or spleen.
Matreya's specialty is in producing high-purity sphingosines, ceramides,
sulfatides, globotriaosylceramides, gangliosides, enzyme inhibitors, tocopherols, and tocotrienols.
Hydrolysis of sulfated glycophospholipids, known as
sulfatides, is not possible due to a lack of enzyme.
MLD is a kind of lysosomal storage disorder due to the deficiency of the ARSA enzyme, which is involved in the metabolism of membrane
sulfatides into galactosylceramide.
Third, Mtb must be able to release virulent factors to damage the host tissue or organs, such as
sulfatides, cord factors, and wax D, components of the cell wall.
P3 is a monoclonal antibody (mAb) of IgM isotype, which recognizes N-glycolylated gangliosides and
sulfatides, both self-antigens in mice [1].
Borsig, "P-selectin mediates metastatic progression through binding to
sulfatides on tumor cells," Glycobiology, vol.
Tourtellotte, "A change in the cerebrosides and
sulfatides in a demyelinating nervous system.
Galactocerebrosides and
sulfatides are major constituent lipids of myelin sheath.
Characterization of urinary
sulfatides in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry.
Other possible serum, CSF, and urine markers include isoprostanes,
sulfatides, oxysterols, homocysteine, apolipoprotein E, alpha 1-antichymotrypsin, 3-nitrotyrosine, and more.
Determination of urinary
sulfatides and other lipids by combination of reversed-phase and thin-layer chromatographies.
