MLD is caused by a mutation in the arylsulfatase-A (ARSA) gene that results in the accumulation of sulfatides
in the brain and other areas of the body, including the liver, the gall bladder, kidneys, and/or spleen.
Matreya's specialty is in producing high-purity sphingosines, ceramides, sulfatides
, globotriaosylceramides, gangliosides, enzyme inhibitors, tocopherols, and tocotrienols.
Hydrolysis of sulfated glycophospholipids, known as sulfatides
, is not possible due to a lack of enzyme.
MLD is a kind of lysosomal storage disorder due to the deficiency of the ARSA enzyme, which is involved in the metabolism of membrane sulfatides
Third, Mtb must be able to release virulent factors to damage the host tissue or organs, such as sulfatides
, cord factors, and wax D, components of the cell wall.
P3 is a monoclonal antibody (mAb) of IgM isotype, which recognizes N-glycolylated gangliosides and sulfatides
, both self-antigens in mice .
Borsig, "P-selectin mediates metastatic progression through binding to sulfatides
on tumor cells," Glycobiology, vol.
Tourtellotte, "A change in the cerebrosides and sulfatides
in a demyelinating nervous system.
Galactocerebrosides and sulfatides
are major constituent lipids of myelin sheath.
Characterization of urinary sulfatides
in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry.
Other possible serum, CSF, and urine markers include isoprostanes, sulfatides
, oxysterols, homocysteine, apolipoprotein E, alpha 1-antichymotrypsin, 3-nitrotyrosine, and more.
Determination of urinary sulfatides
and other lipids by combination of reversed-phase and thin-layer chromatographies.