Caption: Figure 8: The preparation of ZnS QDs/MIP-based fluorescence nanosensor towards sulfapyridine
(reproduced with permission from ).
We show here that 5-ASA decreases toxin A-stimulated colonic [LTB.sub.4] levels and SP release and that 5-ASA but not sulfapyridine
inhibits toxin A-induced colitis.
Thus, sulfamethazine, sulfathiazole, sulfadimethoxine, sulfamerazine, sulfamethoxazole (monitored by the PNCRC/Fish ), sulfapyridine
, sulfamethoxypyridazine, and trimethoprim (regulated for veterinary use , although not regulated for use in fish farming in Brazil) were selected.
Sulfones such as dapsone sulfapyridine
or sulphasalazine rapidly suppress the symptoms of DH.
Quinolone Family May affect cartilage (Ciprofloxacin, development in Norfloxacin, etc.) weight-bearing joints Isoniazid No adverse effects reported Nalidixic Acid Only in infants with G6PD deficiency Nitrofurantoin Only in infants with G6PD deficiency Sulfapyridine
Avoid in infants with G6PD deficiency, and in ill, stressed, or premature infants Sulfisoxazole Avoid in infants with G6PD deficiency, and in ill, stressed, or premature infants Tetracycline Potential for yellow staining of unerupted teeth Antibiotic Recommendation Chloramphenicol Unknown effect on nursing infant, but may be of concern Metronidazole Unknown effect on nursing infant, but may be of concern.
Summary: Two new ligands were synthesized from sulfapyridine
with 5-bromosalicylaldehyde (for L1H) and 5-nitrosalicylaldehyde (for L2H).
Hereditary HbM NADH-MetHb reductase deficiency Acquired Medications Amyl nitrite Benzocaine Dapsone Lidocaine Nitroglycerin Nitroprusside Phenacetin Phenazopyridine Prilocaine Quinones (chloroquinone, primaquine) Sulfonamides (sulfanilamide, sulfathiazide, sulfapyridine
, sulfamethoxazole) Chemical agents Aniline dye derivatives (shoe dyes, inks) Butyl nitrite Chlorobenzene Nitrate-containing foods Isobutyl nitrite Naphthalene Nitrophenol Nitrous gases Silver nitrate Trinitrotoluene Well water nitrates Pediatric Decreased NADH-MetHb reductase activity (<4 months of age) Associated with low birth weight, prematurity, dehydration, acidosis, and diarrhea Table 3.
3,25) Alternative medications include sulfapyridine
, dapsone, and cyclosporine, though disease response is variable and their safety is questionable.
A third drug, sulfasalazine (Azulfidine), is metabolized to 5-ASA plus sulfapyridine
readily crosses the placenta to the fetus.