toxicity and increased resistance to sulfanilamides
Prediction of sulfanilamide
solubility in dioxane-water mixtures.
The sulfa drugs sulfanilamide
, sulfapyridine, and sulfathizole prepared by organic chemistry students were tested in microbiology experiments.
1938) Pathologic effects of elixir of sulfanilamide
(diethylene glycol poisoning).
The Griess reagent consists of sulfanilamide
(58 mM in 3 M HCl) and N-1-naphtylethylenediamine (722 [micro]M).
In 1937, more than a hundred people died in the United States as a result of using a drug formulated with a toxic solvent in what came to be known as the Elixir Sulfanilamide
Carol Ballentine, Taste of Raspberries, Taste of Death: The 1937 Elixir Sulfanilamide
Incident, FDA CONSUMER, June 1981, available at http://www.
Rocky was treated for sulfanilamide
, Bactrim, and Septra (found in meats which putatively block sulfur metabolism in the whole body), 23 different mercury salts, cadmium diazinon, DDT-DDE, insulin, pancreas, benzene, xylene, toluene, dioxin, HGH, PCBs, heptachlor, testosterone, formaldehyde-formic acid, petroleum, atrazine, carbon tetrachloride, methyl ethyl ketone, glucagon, leptin, liver, and heart.
For example, the predecessor of the Food and Drug Administration was empowered to demand premarket approval of drags as a result of poisoning by elixir sulfanilamide
24) See Deaths Following Elixir of Sulfanilamide
-Massengill, 109 JAMA 1367, 1367 (1937); see also Carol Ballentine, Taste of Raspberries, Taste of Death: The 1937 Elixir Sulfanilamide
Incident, FDA CONSUMER, June 1981, at 18, 21.
5 by coupling diazotized sulfanilamide
with N-(1-naphthyl)-ethylenediamine dihydrochloride (NED dihydrochloride).
Massengill's Elixir Sulfanilamide
hit the market in the fall of 1937.