Sulfonamides under study were sulfanilamide, sulfapyridine, sulfadiazine, sulfisomidine, sulfamethoxypyridazine, sulfamethizole, and sulfamethoxazole (Table 1).
Figure 3 shows the comparison between: i) sulfapyridine and sulfadiazine (difference in one nitrogen atom in the heterocyclic moiety), ii) sulfadiazine and sulfisomidine (difference in two methyl groups and in the position of the two nitrogen atoms in the heterocyclic moiety), and iii) sulfamethizole and sulfamethoxazole (difference in one nitrogen atom and the change of a sulfur atom by oxygen atom in the heterocyclic moiety).
SMX), in water-rich mixtures, sulfamethizole was preferentially solvated by water less than sulfamethoxazole ([delta][x.
cholerae isolates to ampicillin (10 [micro]g), ciprofloxacin (5 [micro]g), furazolidone (50 [micro]g), gentamycin (10 [micro]g), neomycin (30 [micro]g), nalidixic acid (30 [micro]g), streptomycin (10 [micro]g), sulfamethizole
(100 [micro]g), tetracycline (30 [micro]g), and trimethoprim (25 [micro]g) were examined by using commercial discs (Hi Media, Bombay, India) as described (1).
Regarding systems of clinical interest, frontal analysis and affinity chromatography have been used to investigate the binding of HSA to R- or S-warfarin (206, 208) and D- or L-tryptophan (205,207,208,213); to determine the binding capacities of monomeric vs dimeric HSA for salicylic acid, warfarin, phenylbutazone, mefenamic acid, sulfamethizole
, and sulfonylureas (230); and to examine the competition of sulfamethizole
with salicylic acid for HSA binding regions (231).