sulfamethizole


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sulfamethizole

 [sul″fah-meth´ĭ-zōl]

sulfamethizole

/sul·fa·meth·i·zole/ (-meth´ĭ-zōl) a sulfonamide used in urinary tract infections.

sulfamethizole (sul´fəmeth´izōl),

n brand name: Thiosulfil Forte;
drug class: sulfonamide, short acting;
action: interferes with bacterial biosynthesis of proteins by competi-tive antagonism of paraaminobenzoic acid (PABA);
use: treatment of urinary tract infections.

sulfamethizole

a short-acting sulfonamide used in urinary tract infections.
References in periodicals archive ?
cholerae isolates to ampicillin (10 [micro]g), ciprofloxacin (5 [micro]g), furazolidone (50 [micro]g), gentamycin (10 [micro]g), neomycin (30 [micro]g), nalidixic acid (30 [micro]g), streptomycin (10 [micro]g), sulfamethizole (100 [micro]g), tetracycline (30 [micro]g), and trimethoprim (25 [micro]g) were examined by using commercial discs (Hi Media, Bombay, India) as described (1).
Because sulfamethoxazole, sulfamerazine, and sulfamethizole contain these groups, they appear to have a greater potential for cross-allergenicity than other sulfonamide antimicrobials.
Regarding systems of clinical interest, frontal analysis and affinity chromatography have been used to investigate the binding of HSA to R- or S-warfarin (206, 208) and D- or L-tryptophan (205,207,208,213); to determine the binding capacities of monomeric vs dimeric HSA for salicylic acid, warfarin, phenylbutazone, mefenamic acid, sulfamethizole, and sulfonylureas (230); and to examine the competition of sulfamethizole with salicylic acid for HSA binding regions (231).
Drug Interactions: In a study in which 34 different drugs were tested, therapeutically relevant concentrations of tolbutamide, sodium salicylate and sulfamethizole displaced protein-bound teniposide in fresh human serum to a small but significant extent.