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One of the components of the triple sulfonamide mixtures.
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The most common residues were sulfamethoxazole (1316 [micro]g/kg) and trimethoprim (239 [micro]g/kg), which are often used as the cotrimoxazole combination, followed by sulfadiazine, sulfathiazole, sulfamerazine, sulfadimidine, tetracycline, epitetracycline, and oxytetracycline.
However, for monitoring purposes (and taking actions), the Brazilian National Plan for Control of Residues and Contaminants (PNCRC/Fish) establishes a reference limit of 100 [micro]g*[kg.sup.-1] for the residue of the individual sulfonamides (sulfachlorpyridazine, sulfadoxine, sulfamerazine, sulfadiazine, sulfamethoxazole, sulfathiazole, sulfamethazine, sulfaquinoxaline, and sulfadimethoxine) or the sum of them.
Rajput, Synthesis and Characterization of Mixed-Ligand Complexes of Cu(II), Ni(II), Co(II), Zn(II), Sm(III), and U(VI)O-2, with a Schiff base Derived from the Sulfa Drug Sulfamerazine and 2, 2 '-bipyridine, Synth.
Daphnia magna showed higher sensibility to ethanol (EC50(I)) than to the chemicals: sulfaquinoxaline (193.3 mg [L.sup.-1]); sulfamethazine (201.1 mg [L.sup.-1]); sulfamerazine (194.6 mg [L.sup.-1]) and sulfadimethoxine (275 mg [L.sup.-1]), while a lesser sensibility was observed in comparison to ciprofloxacin (87.14 mg [L.sup.-1]) (Bona et al., 2014).
Monosubstituted and disubstituted sulfa drugs include sulfadiazine (15), sulfamerazine (16), sulfadimidine (sulfamethazine) (17), sulfameythoxydiazine (18), and methyldiazine (19) (Figure 4).
The sulfonamides selected in this study were sulfadiazine, sulfamerazine, sulfamethazine, sulfamethoxy-pyridazine and sulfamethoxazole (Table 1 and 2).