azole antifungals in this pharmacologic class: clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Kuric), miconazole (Micatin), oxiconazole (Oxistat), sertaconazole (Ertaczo), and
sulconazole (Exelderm).
Antifungal agents are either polyenes (nystatin and am-photericin B) or azoles which are classified into: imidazoles (clotrimazole, econazole, fenticonazole, isoconazole, ketocon-azole, miconazole,
sulconazole, tioconazole); and triazoles (fluconazole, itraconazole).
Options include econazole, ketoconazole, oxiconazole, and
sulconazole.
Clotrimazole, miconazole,
sulconazole, tioconazole, and ketoconazole were shown to inhibit many different P450 enzymes (Zhang et al.
Topical members of this class are clotrimazole, miconazole, econazole, ketoconazole, oxiconazole, and sulconazole.
Current guidelines recommend twice-daily application for clotrimazole, miconazole, and econazole; ketoconazole, oxiconazole, and sulconazole may be applied once daily.
TABLE 3 Topical antifungal medications Agent Formulation Frequency * Duration * IMIDAZOLES Clotrimazole 1% cream Twice daily 2-4 weeks 1% solution 1% swabs Econazole 1% cream Twice daily 2-4 weeks Ketoconazole 2% cream Once daily 2-4 weeks Miconazole 2% cream Twice daily 2-4 weeks 2% spray 2% powder Oxiconazole 1% cream Once to 2-4 weeks 1% lotion twice daily Sulconazole 1% cream Once to 2-4 weeks 1% solution twice daily ALLYLAMINES Naftifine 1% cream Once to 1-4 weeks 1% gel twice daily Terbinafine 1% cream Once to 1-4 weeks 1% solution twice daily BENZYLAMINE Butenafine 1% cream Once to 1-4 weeks twice daily OTHER Ciclopirox 0.
