sulconazole


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sulconazole

 [sul-kon´ah-zōl]
a broad-spectrum topical antifungal agent, used as the nitrate salt in treatment of athlete's foot, ringworm, and Candida infections.
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Molecule in cMap Enrichment score P value Isoflupredone -0.928 0.00054 Trihexyphenidyl -0.922 0.00080 Prestwick-691 -0.856 0.00599 Ajmaline -0.834 0.00903 Carteolol -0.754 0.00734 Thiamphenicol -0.672 0.00883 DL-thiorphan 0.942 0.00632 Milrinone 0.903 0.00182 Apigenin 0.873 0.00036 Ronidazole 0.852 0.00611 Skimmianine 0.835 0.00115 Chrysin 0.826 0.01064 Rottlerin 0.825 0.01074 Clomipramine 0.787 0.00400 Deptropine 0.783 0.00412 Sulconazole 0.783 0.00416 Ethaverine 0.741 0.00863 Ketanserin 0.727 0.01110 Prestwick-685 0.670 0.01045 Resveratrol 0.536 0.00558
azole antifungals in this pharmacologic class: clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Kuric), miconazole (Micatin), oxiconazole (Oxistat), sertaconazole (Ertaczo), and sulconazole (Exelderm).
Antifungal agents are either polyenes (nystatin and am-photericin B) or azoles which are classified into: imidazoles (clotrimazole, econazole, fenticonazole, isoconazole, ketocon-azole, miconazole, sulconazole, tioconazole); and triazoles (fluconazole, itraconazole).
Options include econazole, ketoconazole, oxiconazole, and sulconazole. Clotrimazole and rniconazole remain effective but have the practical drawback of being over the counter.
Options include econazole, ketoconazole, oxiconazole, and sulconazole. Clotrimazole and miconazole remain effective but have the practical drawback of being over the counter.
The fungicidal allylamines (naftifine and terbinafine) and butenafine (allylamine derivative) are a more costly group of topical tinea treatments, yet they are more convenient as they allow for a shorter duration of treatment compared with fungistatic azoles (clotrimazole, econazole, ketoconazole, oxiconazole, miconazole, and sulconazole).
Clotrimazole, miconazole, sulconazole, tioconazole, and ketoconazole were shown to inhibit many different P450 enzymes (Zhang et al.
Topical members of this class are clotrimazole, miconazole, econazole, ketoconazole, oxiconazole, and sulconazole. Miconazole and clotrimazole are available without a prescription.
Current guidelines recommend twice-daily application for clotrimazole, miconazole, and econazole; ketoconazole, oxiconazole, and sulconazole may be applied once daily.