suicide substrate


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su·i·cide sub·strate

a competitive inhibitor that is converted to an irreversible inhibitor at the active site of the enzyme.

suicide substrate

a compound that is not of itself toxic to a cell, but which resembles a normal metabolite closely enough that it undergoes metabolic transformation to a product that does inhibit a crucial enzyme, e.g. fluoroacetate. A substrate-analog that binds irreversibly to amino acids, usually the catalytic amino acid, thereby blocking the active site of the enzyme to other molecules and effectively 'killing' the enzyme.