suicide gene


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suicide gene

A gene that codes for a protein, usually an enzyme, that makes cells vulnerable to otherwise nontoxic substances or nutrients. Suicide genes can be introduced into cells during gene therapy. The technique is used in cancer therapy to make tumor cells susceptible to treatment with prodrugs, which only become active chemotherapeutic agents when they are metabolized within cells harboring the gene. Suicide gene therapy is also used in graft-versus-host disease to kill the activated donor T cells responsible for the immunological attack on the host.

suicide gene

a GENE coding for a product that can kill the CELL. It may be used as a BIOLOGICAL CONTAINMENT stratagem.
References in periodicals archive ?
Genetic engineering also boosts their persistence and embeds a suicide gene that allows the modified cells to be shut down if they cause a severe inflammatory response.
To achieve this, innovative strategies have been implemented to offer compelling opportunities, including suicide gene, targeted activation, and other innovative gene therapy strategies.
We investigated the role of combined cancer gene therapy with Hsulf-1 and cytosine deaminase/5-fluorocytosine (CD/5-FC) suicide gene on a hepatocellular carcinoma (HCC) cell line, HepG2, in vitro and in vivo.
Areas such as stem cell research to address cell loss and division-obsessed cells, suicide gene and immune stimulation to address death resistant cells, age breaking molecules/enzymes for extracellular matrix stiffening--the considerable body of work is cut-out for us and proper funding and awareness is key.
Other firms utilize technology that lastingly turns off CAR-T drugs using what is known as a suicide gene .
So doctors tweaked cells from donors to carry a suicide gene and a unique 'flag' on their outer surface.
However, the dramatic progresses in gene therapy in the past decades have drawn increasing interests in the application of suicide gene system as a new treatment strategy for glioma.
The initial phase of the research found the cancercausing gene causes AML by blocking the "suicide gene" process that naturally kills off cells in the body, so the cancerous cells can live on almost indefinitely.
To test the efficiency of NSCs in targeting and treating breast cancer, the researchers injected NSCs loaded with a suicide gene (herpes simplex virus thymidine) into mice bearing breast tumors.
Cytosine deaminase is employed in the so-called suicide gene therapy to treat tumours.
In vivo suicide gene therapy - antitumour effect of PLTK47.1 and IL-2: NT8e cells (1x[10.sup.7]) were injected subcutaneously in 100 [micro]l HBSS on the right flank of NMRi nude mice.