Genetic engineering also boosts their persistence and embeds a suicide gene
that allows the modified cells to be shut down if they cause a severe inflammatory response.
To achieve this, innovative strategies have been implemented to offer compelling opportunities, including suicide gene
, targeted activation, and other innovative gene therapy strategies.
Chen et al., "Protecting against wayward human induced pluripotent stem cells with a suicide gene
," Biomaterials, vol.
We investigated the role of combined cancer gene therapy with Hsulf-1 and cytosine deaminase/5-fluorocytosine (CD/5-FC) suicide gene
on a hepatocellular carcinoma (HCC) cell line, HepG2, in vitro and in vivo.
Areas such as stem cell research to address cell loss and division-obsessed cells, suicide gene
and immune stimulation to address death resistant cells, age breaking molecules/enzymes for extracellular matrix stiffening--the considerable body of work is cut-out for us and proper funding and awareness is key.
So doctors tweaked cells from donors to carry a suicide gene
and a unique 'flag' on their outer surface.
However, the dramatic progresses in gene therapy in the past decades have drawn increasing interests in the application of suicide gene
system as a new treatment strategy for glioma.
The initial phase of the research found the cancercausing gene causes AML by blocking the "suicide gene
" process that naturally kills off cells in the body, so the cancerous cells can live on almost indefinitely.
To test the efficiency of NSCs in targeting and treating breast cancer, the researchers injected NSCs loaded with a suicide gene
(herpes simplex virus thymidine) into mice bearing breast tumors.
Cytosine deaminase is employed in the so-called suicide gene
therapy to treat tumours.
In vivo suicide gene
therapy - antitumour effect of PLTK47.1 and IL-2: NT8e cells (1x[10.sup.7]) were injected subcutaneously in 100 [micro]l HBSS on the right flank of NMRi nude mice.