sucrose hemolysis test


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sucrose

 [soo´krōs]
a disaccharide obtained from sugar cane, sugar beet, or other sources; used as a food and sweetening agent.
sucrose hemolysis test a test for paroxysmal nocturnal hemoglobinuria; the patient's whole blood is mixed with isotonic sucrose solution, which promotes binding of complement to red blood cells, then incubated and examined for hemolysis; greater than 10 per cent hemolysis indicates paroxysmal nocturnal hemoglobinuria.

su·crose he·mol·y·sis test

isotonic sucrose promotes binding of complement to red blood cells; in paroxysmal nocturnal hemoglobinuria a proportion of the cells is sensitive to complement-mediated lysis, and hemolysis ensues.

sucrose hemolysis test

A screening test for paroxysmal nocturnal haemoglobinuria (PNH), which is based on binding of complement to red cell membranes. In the test, red cells from a patient are incubated in isotonic saline mixed with sucrose in barbital. Lysis of > 10% of tested red cells is typical of PNH.