Biopharmaceutical company QOL Medical LLC revealed on Tuesday the receipt of approval from the US Food and Drug Administration (FDA) to manufacture Sucraid (sacrosidase) Oral Solution for the treatment of congenital Sucrase-Isomaltase
Deficiency at its wholly owned manufacturing facility in Clearwater, Florida.
Of 203 children (mean age, 11.5 years) with chronic abdominal pain who presented to the gastroenterology clinic at Children's Hospital of Wisconsin, the proportion with abnormally low disaccharidase levels in small-intestinal biopsy samples was 37% for lactase, 21% for sucrase, 25% for glucoamylase (which cleaves glucose from maltose or starch), and 8% for palatinase (sucrase-isomaltase
Activities of the brush border enzymes alkaline phosphatase (ALP) and sucrase-isomaltase
(SI) were determined according to the method described previously (25).
and hexose transporter gene expressions are coordinately enhanced by dietary fructose in rat jejunum.
The resultant (maltose, maltotriose, and a-limit dextrins) and sucrose are digested to glucose or fructose by the small intestinal brush border [alpha]-glucosidases (maltase-glucoamylase and sucrase-isomaltase
Oostra, "Primary structure and processing of lysosomal alpha-glucosidase; homology with the intestinal sucrase-isomaltase
complex," EMBO Journal, vol.
These include lactase deficiency (congenital and adult type), sucrase-isomaltase
deficiency, maltase-glucoamylase deficiency, and trehalase deficiency.
And PCR showed the amplification of genes: Membrane metalloendopeptidase (MME), sucrase-isomaltase
(SI), butyrylcholinesterase (BCHE), and kininogen (KNG).
Localization of sucrase-isomaltase
in the rat enterocyte.
Therefore, we consider that FT is another type of differentiation marker, different from the intestinal digestive enzyme such as sucrase-isomaltase
complex expressed in the villus differentiated epithelial cells just in the weaning stage in both CV and GF mice.
Lodish, "The sucrase-isomaltase
complex: primary structure, membrane-orientation, and evolution of a stalked, intrinsic brush border protein," Cell, vol.
Barbat et al., "Differential expression of sucrase-isomaltase
in clones isolated from early and late passages of the cell lineCaco-2: Evidence for glucose-dependent negative regulation," Journal of Cell Science, vol.