Biopharmaceutical company QOL Medical LLC revealed on Tuesday the receipt of approval from the US Food and Drug Administration (FDA) to manufacture Sucraid (sacrosidase) Oral Solution for the treatment of congenital Sucrase-Isomaltase Deficiency at its wholly owned manufacturing facility in Clearwater, Florida.
Of 203 children (mean age, 11.5 years) with chronic abdominal pain who presented to the gastroenterology clinic at Children's Hospital of Wisconsin, the proportion with abnormally low disaccharidase levels in small-intestinal biopsy samples was 37% for lactase, 21% for sucrase, 25% for glucoamylase (which cleaves glucose from maltose or starch), and 8% for palatinase (sucrase-isomaltase).
The resultant (maltose, maltotriose, and a-limit dextrins) and sucrose are digested to glucose or fructose by the small intestinal brush border [alpha]-glucosidases (maltase-glucoamylase and sucrase-isomaltase) .
Therefore, we consider that FT is another type of differentiation marker, different from the intestinal digestive enzyme such as sucrase-isomaltase complex expressed in the villus differentiated epithelial cells just in the weaning stage in both CV and GF mice.
Barbat et al., "Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell lineCaco-2: Evidence for glucose-dependent negative regulation," Journal of Cell Science, vol.