NEW ORLEANS -- Succinobucol, a novel antioxidant with anti-inflammatory properties, achieved a 64% reduction in new-onset diabetes in patients with a recent acute coronary syndrome in the phase III Aggressive Reduction of Inflammation Stops Events (ARISE) trial.
Succinobucol failed to achieve a significant impact on the primary end point, a composite of "hard" atherosclerotic outcomes and the "soft" end points of coronary revascularization and hospitalization for unstable angina, said Dr.
The 6,144 ARISE participants were randomized to 300 mg/day of succinobucol or placebo for an average of 2 years starting shortly after hospitalization for an acute MI or unstable angina.
Among the other nearly 4,000 participants, the incidence of new-onset diabetes was 4.2% with placebo and 1.6% with succinobucol, a 64% relative risk reduction.
The combined "hard" secondary atherosclerotic end point of cardiovascular death, cardiac arrest, MI, or stroke occurred in 8.2% of the placebo group and 6.7% with succinobucol, for a significant 19% relative risk reduction.
The 6,144 ARISE participants were randomized to 300 mg/day of succinobucol or placebo for a mean of 2 years starting shortly after hospitalization for an acute MI or unstable angina.
Succinobucol, a potent lipophilic antioxidant, is the monosuccinic acid ester of probucol.