succinate dehydrogenase


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suc·ci·nate de·hy·dro·gen·ase

a flavoenzyme that catalyzes the removal of hydrogen from succinic acid and converts it into fumaric acid; for example, succinate + FAD ⇄ fumarate + FADH2; this complex is a part of the tricarboxylic acid cycle.

muscle enzymes

the table lists some of the most often-mentioned enzymes present in skeletal muscle, with their locations and functions. Apart from actomyosin and myosin ATPases which are associated with the contractile mechanism, they are by no means specific to muscle, being present and highly active also in other tissues. See also Krebs cycle, muscle fibre types.
Table 1: Muscle enzymes
Name SiteCatalyses…
Actomyosin ATPase (amATPase) myosin head groups hydrolysis (Mg-dependent and triggered by rise in [Ca2+]) of terminal phosphate group of ATP when head-group is in interaction with actin, releasing energy that powers force- generation. (Compare myosin ATPase)
Creatine kinase (CK) cytoplasm transfer of phosphate group from creatine phosphate to ADP, producing ATP and creatine. Isoenzymes can be distinguished in blood when either skeletal or cardiac muscle has been damaged.
Hexokinase (HK) cytoplasm 'capture' of glucose after uptake from the blood, by conversion to the impermeant glucose 6-phosphate, in type 1 muscle fibres, which utilize glucose directly.
Lactate dehydrogenase (LDH) cytoplasm reduction of pyruvate to lactate when oxygen tension is low, and the converse when it is high. Isoenzymes can be distinguished in blood when either skeletal or cardiac muscle has been damaged.
Myosin ATPase (mATPase) myosin head groups hydrolysis (Ca2+ dependent, Mg2+ independent) of terminal phosphate group of ATP by head group alone, not interacting with actin (so not contraction-producing: cf actomyosin ATPase). Basic histochemical marker for fast vs. slow fibres.
Phosphofructokinase (PFK) cytoplasm conversion of fructose 6-phosphate to fructose 1,6-diphosphate; rate-limiting for glycolysis, and sensitive to very many stimulatory and inhibitory influences.
Phosphorylase (PPL) cytoplasmremoval of hexose units, one at a time, from glycogen, to form glucose 1-phosphate: rate-limiting enzyme of, and histochemical marker for, glycogenolysis.
Pyruvate dehydrogenase (PDH) mitochondrial envelope oxidative decarboxylation of pyruvate (from cytoplasm) to form acetyl CoA, which thence feeds into tricarboxylic acid (Krebs) cycle
Sarcoplasmic reticulum ATPase (srATPase) SR membrane pumping of [Ca2+] back into SR after its electrically stimulated release
Succinate dehydrogenase (SDH) mitochondrial inner membrane oxidation of succinate to fumarate, in tricarboxylic acid (Krebs) cycle. Histochemical marker for aerobic capacity.

succinate

any salt of succinic acid.

succinate dehydrogenase
an enzyme of the TCA cycle, located in the inner mitochondrial membrane that splits off hydrogen from succinic acid.
References in periodicals archive ?
However, Succinate dehydrogenase activity was recorded rich in the species of Rhodophyceae which shown the range of 0.
Activity of glycogen phosphorylase (GP) and the content of glycogen in cytosolic fraction and the activities of isocitrate dehydrogenase (ICDH) and succinate dehydrogenase (SDH) in mitochondria liver and skeletal muscle of experimental animals Parameters CON FRU GP (A): Liver 4.
A number of previous reports have examined the activity of succinate dehydrogenase in aging.
Medium and high activities of phenoloxidase and succinate dehydrogenase, respectively, were found in axial an radial parenchyma lumina towards vascular cambium.
Professor So Iwata of Imperial College London, who led the research, reported in the journal Science, ``Solving the structure of succinate dehydrogenase opens up new leads in the quest to understand longevity and ageing.
13] Recent studies have shown a germ line mutations in succinate dehydrogenase (SDH), leading to complete loss of SDH protein.
At the cellular level, 3NPA inhibits succinate dehydrogenase [4, 5], a key enzyme of oxidative energy production that is localized in the mitochondrial inner membrane and complex II of the respiratory chain, causing ATP levels in the brain to fall.
We used this enzymatic test, based on the cleavage of MTT into a blue-colored product (formazan) by mitochondrial enzyme succinate dehydrogenase (Mossman 1983), to evaluate JEG3 cell viability exposed to Roundup or glyphosate during various times.
These genes included succinate dehydrogenase (SDHC), cytochrome c oxidase (COX5B/ COX6B), and various genes of the ATP synthase complex (ATP5G1, ATP5C1, ATP5J, ATP5B, ATP5A1, ATP50, and ATP5F1).
2 translocation-associated renal cell carcinoma; p63, high-molecular-weight cytokeratin and racemase cocktail [PIN4]/phosphatase and tensin homolog [PTEN] for some cases of intraductal carcinoma of the prostate; and succinate dehydrogenase subunit B in renal cell carcinoma and pheochromocytoma), amyloidosis of the genitourinary tract, and workup of neoplastic needle core kidney biopsies.