succinate


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succinate

 [suk´sĭ-nāt]
any salt, ester, or anionic form of succinic acid.

suc·ci·nate

(sŭk'si-nāt),
A salt of succinic acid.
Succinateclick for a larger image
Fig. 292 Succinate . Molecular structure.

succinate (succinic acid)

a 4-carbon DICARBOXYLIC ACID found in the KREBS CYCLE (see Fig. 292 ). It is formed from succinyl CoA by the ENZYME succinyl CoA synthetase. This is the only step in the cycle that directly yields a high energy bond. Succinate is subsequently oxidized to fumarate by the enzyme succinate DEHYDROGENASE.
References in periodicals archive ?
Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients.
Patients in the control group underwent vertebral body decompression, bone grafting and internal fixation according to the severity of spinal cord compression, while patients in the observation group were treated by methylprednisolone sodium succinate in addition to the same treatment as the control group.
Toward homosuccinate fermentation: Metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate from glucose and formate.
About 7-10% of GISTs have loss of function of the succinate dehydrogenase complex on inner mitochondrial membrane.
There was no evidence of amino acid, acetate, succinate, alanine peaks in contrast to pyogenic abscess.
We therefore discarded metabolites influenced by confounding variables, and we found six candidates with statistically significant differences in concentration between the control group and PAD patients: 3-hydroxybutyrate, a-ketoglutarate, glutamate, glutamine, (iso)citrate, and succinate. These candidates were useful to distinguish between PAD patients and the control group and also to discriminate between different clinical stages.
Accordingly, certain cancers are associated with genetic aberrations in TCA cycle enzymes, such as isocitrate dehydrogenase 1 (IDH1), isocitrate dehydrogenase 2 (IDH2), succinate dehydrogenase (SDH), fumarate hydratase (FH), and L-2-hydroxyglutarate dehydrogenase.
The assay was performed with 10 [micro]g of mitochondrial protein in KCl-based medium (120 mM KCl, 3 mM HEPES, 5 mM K[H.sub.2]P[O.sub.4], 3 mM MgS[O.sub.4], 1 mM EGTA, 3mg/mL BSA, pH 7.2) supplemented either with 10 mM pyruvate plus 2mM malate, 10 mM succinate, or 10 mM GP.
reported that ischemic accumulation of succinate controls redox dynamics of reperfusion injury through mitochondrial reactive oxygen species.
Thermal decomposition temperatures of the starch succinate (SS) and cross- linked starch succinate (CLSS) were analyzed using TA Instruments equipped with a thermo-balance (SDT Q600 USA).
A/ THREE BETA-BLOCKERS--CARVE DILOL, METOPROLOL SUCCINATE, AND BISOPROLOL--reduce mortality equally (by about 30% over one year) in patients with Class III or IV systolic heart failure.