succinate


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succinate

 [suk´sĭ-nāt]
any salt, ester, or anionic form of succinic acid.

suc·ci·nate

(sŭk'si-nāt),
A salt of succinic acid.

succinate

/suc·ci·nate/ (suk´sĭ-nāt) any salt or ester of succinic acid.
succinate semialdehyde  γ.
Succinateclick for a larger image
Fig. 292 Succinate . Molecular structure.

succinate (succinic acid)

a 4-carbon DICARBOXYLIC ACID found in the KREBS CYCLE (see Fig. 292 ). It is formed from succinyl CoA by the ENZYME succinyl CoA synthetase. This is the only step in the cycle that directly yields a high energy bond. Succinate is subsequently oxidized to fumarate by the enzyme succinate DEHYDROGENASE.

succinate

any salt of succinic acid.

succinate dehydrogenase
an enzyme of the TCA cycle, located in the inner mitochondrial membrane that splits off hydrogen from succinic acid.
References in periodicals archive ?
dramatically advanced our understanding of impaired succinate pathways in reperfusion ischemic injury, whereas no evidence for similar impairment was developed in the 2004 study.
Photomicrograph showing chief cells, which are immunoreactive for succinate dehydrogenase B (original magnification X20).
Result of thermal studies and degradation kinetics has revealed that thermal properties of the starch succinate were significantly improved after cross-linking.
The conventional therapy of chronic bacterial prostatitis with subsequent corrections of spermatogenesis against the background of the constant reception of ethylmethylhydroxypyridine succinate allows suppressing pathospermia and bringing the basic parameters of the ejaculate in accordance with guideline values (WHO, 2010) in more than 80% of cases.
Hall and Baker, (1978) studied acute effects of single intravenous doses of methyl prednisolone sodium succinate (30, 60, or 90 mg/kg) on segmental spinal cord function.
This case might be an important reminder to all medical personnel, that any patients can have allergic reactions to parenteral corticosteroids containing succinate.
According to the detected genes for glucose metabolism, they elucidated the fungal carbohydrate metabolism pathway and postulated that the metabolites for Neocallimastix frontalis were acetate, ethanol, formate, lactate, succinate and a-ketoglutarate, which was oxidized from oxaloacetate by aconitase and isocitrate dehydrogenase.
Both types of tumors are associated with conditions that are inherited in an autosomally dominant manner, such as: multiple endocrine neoplasia type 2 (MEN2), [2] which is due to a mutation in the RET [3] (ret proto-oncogene) protooncogene; von Hippel-Lindau disease (VHL), which is due to a mutation in the VHL (von Hippel-Lindau tumor suppressor) gene; neurofibromatosis type 1 (NF1), caused by mutation in the NF1 (neurofibromin 1) gene; and mutations in succinate dehydrogenase (SDH) subunits B, C, and D, which are encoded by the SDHB [succinate dehydrogenase complex, subunit B, iron sulfur (Ip)], SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa), and SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein) genes.
The homogenate was centrifuged at 10,000 g for 20 minutes and the supernatant was used as enzyme source for the assay of proteases, peroxidase, succinate dehydrogenase and polyphenoloxidase activities which were measured by the standard methodologies.
Pharmaceutical and biotechnology company Wockhardt Ltd said it received approval from the US Food and Drug Administration (USFDA) for marketing an extended-release tablets of metoprolol succinate.
The new study reports identification of three chemicals - betaine, glutamate, and succinate - that V.
Tokyo, Oct 5, 2009 - (JCN) - Mitsubishi Chemical Corporation and PTT Public Company Limited, headquartered in Bangkok, have agreed to study the development of bio-polybutylene succinate, a bio-degradable polymer, made from biomass resources in Thailand, as of September 25, 2009.