is used most often for chelation, although calcium disodium EDTA and dimercaprol are still used in some cases.
Although approved for the treatment of lead poisoning, succimer
is used off-label for treating mercury toxicity (5).
Cadmium induced testicular damage and its response to administration of succimer
and diphenyl diselenide in mice.
The treatment of lead poisoning from gunshot wounds with succimer
treatment and calcium supplementation reduce tissue lead in suckling rats.
The analysis of patient data from 1,280 individuals in nine cohort studies also showed a polymorphonuclear cell count of greater than 60% nearly doubled the risk while the presence of grades IV-V vesicoureteral reflux was associated with a 22-fold increase in the likelihood of renal scarring, defined as presence of photopenia on a technetium Tc 99m succimer
There are six agents available to treat heavy metal (arsenic, gold, iron, lead, and mercury) intoxication: de-ferasirox (iron), deferoxamine (iron), dimercaprol (arsenic, gold, lead, and mercury), edetate calcium disodium (lead), penicillamine (copper and mercury), and succimer
chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure.
A comparison of sodium calcium edentate (edentate calcium disodium) and succimer
(DMSA) in the treatment of organic lead poisoning.
Some families have turned to succimer
as an alternative therapy for treating autism.
Lead induced oxidative stress and its recovery following co-administration of melatonin or n-acetylcysteine during chelation with succimer
in male rats.
Se han utilizado diversos agentes como terapia quelante en la intoxicacion con mercurio, entre ellos: succimer
, dimercaprol, D-penicilamina y N-acetilcisteina; en Colombia se dispone de los dos ultimos.