Dimercaptosuccinic acid (succimer
; DMSA) in inorganic lead poisoning.
The poison-control team was consulted upon admission and recommended starting the patient on succimer
, as a chelating agent, to be given in a dose of 500 mg every eight hours for the first 5 days then every twelve hours for the 14 days.
Food and Drug Administration in 1991 approved an oral chelator called dimercaptosuccinic acid, or succimer
. Today, succimer
is used most often for chelation, although calcium disodium EDTA and dimercaprol are still used in some cases.
, an oral chelating agent used to remove lead and heavy metals from the body, was recommended by the Southeast Pediatric Environmental Health Specialty Unit and the Florida Poison Information Center Tampa for seven patients.
Cadmium induced testicular damage and its response to administration of succimer
and diphenyl diselenide in mice.
Chelation agents include the oral agent succimer
, the intramuscular agent dimercaprol, and the intravenous agent CaEDTA [19-21].
Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer
in male rats.
The treatment of lead poisoning from gunshot wounds with succimer
treatment and calcium supplementation reduce tissue lead in suckling rats.
The analysis of patient data from 1,280 individuals in nine cohort studies also showed a polymorphonuclear cell count of greater than 60% nearly doubled the risk while the presence of grades IV-V vesicoureteral reflux was associated with a 22-fold increase in the likelihood of renal scarring, defined as presence of photopenia on a technetium Tc 99m succimer
There are six agents available to treat heavy metal (arsenic, gold, iron, lead, and mercury) intoxication: de-ferasirox (iron), deferoxamine (iron), dimercaprol (arsenic, gold, lead, and mercury), edetate calcium disodium (lead), penicillamine (copper and mercury), and succimer
chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure.