subventricular zone


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subventricular zone

[-ventrik′yələr]
an area, located between the ventricular and intermediate zones in the fetal forebrain, in which neurons of the cerebrum are generated.
References in periodicals archive ?
v]1 = Shaker-type voltage-gated potassium channel, M1 = primary motor cortex, Nav = voltage-gated sodium channel, NGF = nerve growth factor, OB = olfactory bulb, OEC = olfactory ensheathing cell, OM = olfactory mucosa, ONL = outer nerve layer, ORN = olfactory receptor neuron, p75NGFR = p75 NGF receptor, PNS = peripheral nervous system, RMS = rostral migratory stream, SCI = spinal cord injury, SVZ = subventricular zone.
The finding may prove a boon for investigators seeking to grow nerve cells in the laboratory because the subventricular zone of the brain may provide a pure source of neurons, says Luskin.
According to the researchers, recent studies suggest adult neurogenesis in the brain's subventricular zone (SVZ), which lines the ventricles (cavities) of the brain that contain cerebrospinal fluid, plays a role in reproductive function and possibly in maternal behaviors, although the function of "SVZ neurogenesis is obscure.
The most active neurogenesis occurs in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus (3, 4).
The researchers found increased numbers of new neurons in the subventricular zone in adult, nulliparous rats that behaved maternally compared with numbers in subjects that either were not exposed to young or exposed to young, but did not behave maternally.
Importantly, treatment with arimoclomol initiated at all four time points following the stroke event significantly increased the number of newly developing neurons in both the zone surrounding the lesion, as well as in an area called the subventricular zone of the lateral ventricle - the typical origin of these cells prior to their migration to the damaged tissue.
For the first time, the findings in mice show that Glioblastoma may originate in neural stem cells located in a brain region known as the subventricular zone (SVZ).
Once the initial experiments conducted by the researchers confirmed that their approach was working, they injected lentiviruses carrying two well-known oncogenes, H-Ras and Akt, into three separate brain regions of mice lacking one copy of the gene encoding the tumor suppressor p53: the hippocampus, which is involved in learning and memory; the subventricular zone, which lines the brain's fluid-filled cavity; and the cortex, which governs abstract reasoning and symbolic thought in humans.