Although it's well known that patients frequently don't achieve therapeutic doses of antibiotics that effectively clear their infections, it's been unclear how microbial diversity changes in patients who receive subtherapeutic
doses compared with patients who receive therapeutic doses.
Miltefosine is also a good option in patients who are resistant to pentavalent antimony or exhibit cross-resistance to amphotericin B.6 The terminal half-life of miltefosine is long which ranges between 150 and 200 hours and about four half-lives (25-33 days) are needed to reach more than 90% of the peak levels, thereby a subtherapeutic
level of miltefosine may remain for some weeks after a 4 week course.8 This feature might encourage the emergence of resistance but it can be prevented by ensuring good compliance and adequate dosing for adequate duration or by using combination therapies.8
patients with atrial fibrillation hospitalized for an ischemic stroke 84% had received inadequate anticoagulation with either subtherapeutic
dosages of anticoagulant or no anticoagulant at all (JAMA.
* To study the interaction of liraglutide and teneligliptin on inflammation with subtherapeutic
equivalent anti-inflammatory dose of ibuprofen.
Serum itraconazole level was repeated and found to be subtherapeutic
(<0.1 mcg/mL; normal [greater than or equal to] 0.6 mcg/mL).
All INR measurements, except measures after readmission, in each group were used to calculate the percentage of INR values in therapeutic and out of therapeutic range (subtherapeutic
The urine drug screen was positive for amphetamines and her lithium level was subtherapeutic
In most cases, a triggering event can be identified including infection, withdrawal of (or subtherapeutic
levels of) anticoagulation, and coexistence of systemic lupus erythematosus (SLE) flare (1, 2).
Although TB is typically a treatable disease, cases of multidrug resistant TB (MDR-TB) that are resistant to the first-line drugs rifampin and isoniazid have emerged in recent years, presumably due to inadequate treatment or subtherapeutic
Certain classes of antimicrobials may likewise be affected by ECMO, potentially leading to subtherapeutic
drug concentrations if usual dosing regimens are used.
The solution industry has used is to administer low-level (subtherapeutic
) doses of antibiotics in the animals' food or water for long periods of time prophylactically to prevent infections.
In some cases, ingredient mixing is inefficient, with doses ranging from subtherapeutic
to directly toxic.