subthalamic nucleus

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Related to subthalamic nucleus: striatum, globus pallidus, caudate nucleus

sub·tha·lam·ic nu·cle·us

a circumscript nucleus, shaped like a biconvex lens, located in the ventral part of the subthalamus on the dorsal surface of the peduncular part of the internal capsule immediately rostral to the substantia nigra. The nucleus receives a massive topographic projection from the lateral segment of the globus pallidus and a somatopically organized projection from the ipsilateral motor cortex; a smaller bundle of afferents from the centromedian nucleus of the thalamus terminates in the rostral part of the nucleus The subthalamic nucleus projects to both pallidal segments, to the pars reticulata of the substantia nigra, and in a small way to the ipsilateral pedunculopontine nucleus.

subthalamic nucleus

a biconvex mass of gray matter on the medial side of the junction of the internal capsule and the crus cerebri. Its chief connections are with the globus pallidus.

subthalamic nucleus

A basal ganglia nucleus that is found under the thalamus in the base of the diencephalon; it lies between the thalamus and the cerebral peduncle, just rostral to the substantia nigra. The subthalamic nucleus is a satellite of the globus pallidus with which it has reciprocal connections. Lesions of the subthalamic nucleus on one side of the brain produce hemiballismus.
See also: nucleus


Jules B., French physician, 1828-1897.
centre médian de Luys - Synonym(s): centromedian nucleus
corpus luysi - Synonym(s): subthalamic nucleus
Luys body - Synonym(s): subthalamic nucleus
Luys body syndrome
nucleus of Luys - Synonym(s): subthalamic nucleus
References in periodicals archive ?
The subthalamic nucleus (STN) plays an important role in motor programs during locomotion.
These findings are consistent with other data suggesting that following stimulation of the subthalamic nucleus PD patients were still more than 40% slower in completing tasks than are controls.
Subthalamic nucleus deep brain stimulation does not appear to change the course of Parkinson's disease when it is performed on patients with long-standing disease.
He had begun working with Parkinson's patients because DBS, a treatment that suppresses their tremor symptoms, delivers pulses of electrical current to the subthalamic nucleus (STN), a part of the brain that Frank hypothesized had an important role in decisions.
The subthalamic nucleus (STN) has become the preferred and most common target of deep brain stimulation for Parkinson's disease patients, even though "there really is a lack of high-quality evidence that STN-DBS provides clinical outcomes that are superior to outcomes with GPi [globus pallidus interna]-DBS," said Dr.
By implanting electrodes into the subthalamic nucleus to provide a constant stimulation pulse, this over-activity can be inhibited, allowing the patient, to all external intents and purposes, to function normally.
Mazzone's research team in Rome goes on to suggest that the combined stimulation of the traditionally implanted subthalamic nucleus plus PPN is more valuable than PPN stimulation alone.
Stimulation of a new target, the subthalamic nucleus (STN), has been shown to improve all levodopa-responsive motor symptoms of PD (Limousin et al.
After the drug's effect had worn off, the researchers temporarily inserted a hair-thin electrode into each volunteer's brain to measure electrical signals emitted by cells in a Parkinson's-implicated area called the subthalamic nucleus.
The study, conducted at seven Veterans Affairs and six university hospitals with participation from 299 patients, compared the 24-month results of patients assigned randomly to receive DBS via one of the two common targets in the brain - the subthalamic nucleus (STN) or globus pallidus interna (GPi).