Key results from a series of in vitro, in situ and in vivo rodent experiments demonstrated that treatment with CK-2066260: Amplified the muscle force response to subtetanic
electrical stimulation by increasing muscle calcium sensitivity; Improved the force response under fatiguing conditions; Produced muscle force at lower cytosolic calcium concentrations and accompanied by reduced ATP demand and muscle glycogen usage; Improved exercise capacity in healthy rats and a rat model of peripheral artery insufficiency.
A recent report on a new NMES approach has demonstrated that repeated application of low-frequency currents to elicit subtetanic isometric contractions in leg muscles results in significant aerobic training effects in SCI [17-18].
Therefore, the objective of this investigation was to investigate alterations in body composition (BC) and spasticity following 8 wk of training with the subtetanic NMES application.
Subtetanic contractions in the quadriceps and hamstrings were elicited using a battery-powered muscle stimulator (NT2010, Biomedical Medical Research; Galway, Ireland).
The principal finding of this study was that an 8 wk training program with a subtetanic NMES protocol for the quadriceps and hamstrings resulted in a significant increase in LBM and a significant decrease in spasticity in a cohort of adults with SCI.