substrate specificity

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Related to substrate specificity: Lock and Key Model, Lock and Key Theory

sub·strate spec·i·fic·i·ty

the ability of an enzyme to recognize and bind its substrates, typically measured by the Vmax/Km or kcat/Km ratios.


any substance upon which an enzyme acts.

substrate binding site
part of the active site of an enzyme which includes the amino acid residues that come into contact with the substrate.
substrate specificity
range of substrates that can be catalytically converted to product by an enzyme.
suicide substrate
References in periodicals archive ?
We hypothesized that these hydrophobic residues might mediate substrate specificity in SPCs by impacting the ability of a specific SPC to recognize and bind to a specific proprotein.
In this genome, there are nine copies of a P-type ATPase with a predicted substrate specificity for divalent cations.
Ubiquitin Research Tools: Novel technologies such as the CHOP reporter and soon to be introduced Ubiquitin Ligase Kits will allow researchers to demonstrate novel isopeptidase activity, determine substrate specificity of a Ub/Ubl isopeptidase, and measure activity of difficult enzymes such as the Cop9 signalosome.
The substrate specificity of TK2 is different from that of TK1, e.
Using extensive genetic sequence and functional data collected from these samples, Diversa scientists were, for the first time, able to predict enzymatic substrate specificity, or the precise function of an enzyme, based on genetic sequence information.
There are several isoforms of carboxylesterases that have been classified based on substrate specificity and their isoelectric point (26).
IMP] in being carried on an integron-borne mobile gene cassette and in encoding an enzyme (VIM-1) with broad substrate specificity (3).
Matrilysin (MMP7) is a protease with broad substrate specificity, being able to degrade elastin, proteoglycans, fibronectin, and type IV collagen.
The substrate specificity of caspase 8 is different from other caspases, for example caspase 3," noted Joe Wu, Ph.
Differences in Substrate Specificity of C(5)-Substituted or Unsubstituted Pyrimidine Nucleotides by DNA Polymerases from Thermophilic Bacteria, Archae, and Phage (H.
On the other hand, human glandular kallikrein 2 (hK2), which shares 79% amino acid structure homology with PSA, has a trypsin-like substrate specificity (13, 14).
The grant will support development of an advanced form of Phage Display technology to be used for rapid production of industrial enzymes with improved catalytic activity and substrate specificity.