substrate specificity


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Related to substrate specificity: Lock and Key Model, Lock and Key Theory

sub·strate spec·i·fic·i·ty

the ability of an enzyme to recognize and bind its substrates, typically measured by the Vmax/Km or kcat/Km ratios.

substrate

any substance upon which an enzyme acts.
substrate binding site
part of the active site of an enzyme which includes the amino acid residues that come into contact with the substrate.
substrate specificity
range of substrates that can be catalytically converted to product by an enzyme.
suicide substrate
see suicide substrate.
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References in periodicals archive ?
The observation of substrate specificity showed that CtCel6 displayed high activity towards b-D-glucan with 1.
A Novel Application Potential of GH6 Cellobiohydrolase CtCel6 from Thermophilic Chaetomium thermophilum for Gene Cloning, Heterologous Expression and Biological Characterization
Structure of a class HI engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity, Biochem.
Cephalosporin C acylase from microbes for one-step enzymatic transformation of cephalosporin C to 7-aminocephalosporanic acid
Various substrates were tested to determine substrate specificity of the recombinant NfAXE1 under optimum conditions (40[degrees]C, pH 8).
Characterization of heterologously expressed acetyl xylan esterase1 isolated from the anaerobic rumen fungus Neocallimastix frontalis PMA02
This broad range of substrate specificity was similar to those of other plant acid phosphatases (Tejera- Garcia et al.
PARTIAL PURIFICATIONCHARACTERIZATION AND SOME KINETIC PROPERTIES OF LOW MOLECULAR WEIGHT ACID PHOSPHATASE FROM LEAVES OF GERMINATING VIGNA RADIATA SEEDS
The activity or the apparent substrate specificity is variable with various substances, and so in other words, a PLB could be amenable to the circumstances.
Reminiscence of phospholipase B in Penicillium notatum
The enzymes belonging to this class vary significantly in substrate specificity, which can correspond to the requirements of ecological niches of the fungi [26].
Serine proteinases secreted by two isolates of the fungus alternaria solani
The phenolic ring on these BFRs superimposes well with that of the acceptor phenol of E2, and is selected for by steric gate residues Phe80 and Phe141, which have been reported to contribute toward substrate specificity (Petrotchenko et al.
Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis
Redesigning trypsin: alteration of substrate specificity, catalytic activity and protein conformation.
Lobster (Panulirus argus) hepatopancreatic trypsin isoforms and their digestion efficiency
This should certainly complicate theoretical analysis of the substrate specificity of protein kinase A and the specificity of bisubstrate enzymes in general.
Single-subunit allostery in the kinetics of peptide phosphorylation by protein kinase A/proteiinkinaasi a kataluutilise alauhiku allosteeria ilmnemine peptudide fosforuleerimise kineetikas
Most plant acid phosphatases show little substrate specificity, exhibit an optimum pH below 6.
Presenca de atividade de multiplas fosfatases acidas em plantulas de pepino, rabanete e rucula
The available data about the enzyme substrate specificity towards different substrates vary widely and are different for enzyme preparations from different sources.
Purification and properties of amine oxidase from pea seedlings/Amiini oksudaasi puhastamine ja omadused
Novozymes A/S (Bagsvaerd, Denmark) has patented a method for modifying the substrate specificity of a lipolytic enzyme by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity.
Novozymes obtains United States patent

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