substrate inhibition

sub·strate in·hi·bi·tion

inhibition of an enzyme activity by a substrate of the reaction catalyzed by that enzyme; often, this type of inhibition occurs at elevated substrate concentrations in which the substrate is binding to a second, non-active site on the enzyme.
Mentioned in ?
References in periodicals archive ?
The natural of cephalosporin C acylase catalyzed the CPC to 7-ACA directly in a very low efficiency (14,15,16), significant substrate inhibition (14), and product inhibition (14).
The two binding sites have been used to explain the activation and substrate inhibition and biphasic saturation curves for the cytochrome P450 enzymes [52].
This is consistent with work that demonstrated substrate inhibition via an allosteric binding site (Zhang et al.
1] = 1, if p =1 and q = 2 (2) corresponds to a substrate inhibition model [8] and if p = q = 2 (2) can be interpreted in terms of an allosteric mechanism [4, 9].
On the other hand, the Haldane model could be taking into account a possible substrate inhibition effect at a higher concentration even though the dependence [OUR.
Substrate inhibition appeared in SHF when cassava starch reached 70 g/L due to the relatively weak toleration to initial sugar concentration.
Biosensor response at mixed enzyme kinetics and external diffusion limitation in case of substrate inhibition, Nonlinear Analysis: Modeling and Control 11(4): 385-392.
Some inhibitory effect is revealed in the presence of excess of ATP, while for the peptide counterpart of the reaction no substrate inhibition was observed within the concentration interval used.
We have deliberately adapted the title of a paper published in 1978 by Ellis and Duggleby [1] because we have noticed the use of substrate inhibition (SI) models of enzyme kinetics that are not justified by the data [2-4].
The observation of substrate inhibition due to phenol can be modeled using substrate inhibition models described in literature16.
Adsorption also caused a lowering of the phenol concentration in solution with a concomitant reduction in the substrate inhibition effect on cell growth.