substantial pain

substantial pain

Pain of a severity sufficient to impair function. See Brief Pain Inventory, Pain.
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A patient may not respond to multiple treatment modalities, thus keeps suffering from substantial pain for months and even years.
All your victims suffered substantial pain, distress and discomfort.
People who suffer from episodic migraine experience substantial pain, disability and physical impairment, which can significantly disrupt their ability to participate in everyday activities," said Vasant Narasimhan, Global Head Drug Development and Chief Medical Officer for Novartis.
It causes substantial pain and suffering, among adults and children alike.
Constitution's Eighth Amendment prohibition against "cruel and unusual punishment" because it cannot reliably produce a deep, coma-like unconsciousness that will prevent substantial pain caused by the effects of the second and third drugs.
Hence the adoption of analgesia protocol of combining analgesic and antispasmodic drugs in smaller optional synergistic doses proved to be an asset in providing substantial pain relief.
Kirkilie claims to have suffered substantial pain and suffering, and she says the injury has permanently altered her appearance.
According to Retrophin, Thiola is approved by the US Food and Drug Administration for the treatment of cystinuria, a rare genetic cystine transport disorder that causes high cystine levels in the urine and the formation of recurring kidney stones, causing loss of kidney function, substantial pain and loss of productivity associated with renal colic and stone passage.
While only approximately 5% of all bladder stones occur in women, this condition can result in significant clinical symptomology (irritable bladder, urinary tract infection) and substantial pain.
Chantry said: "As well as eventually being fatal, myeloma causes substantial pain and loss of mobility.
Tramadol is supported by "modest" evidence of efficacy as an add-on niche medication for patients with substantial pain despite their baseline medications, the rheumatologist continued.
ISLAMABAD -- "There is a substantial pain that the low income countries suffer due to immigration of highly educated to high income countries.