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1. physical material that has form and weight; called also matter.
2. the material constituting an organ or body.
substance Abuse and Mental Health Services Administration (SAMHSA) an agency of the United States Department of Health and Human Services, created in 1992 to oversee the quality and availability of programs for prevention, treatment, and rehabilitation of substance abuse and related mental health problems.
black substance substantia nigra.
controlled substance a psychoactive substance that is regulated under the controlled substances act. See table at drug dependence.
depressor substance
gray substance gray matter.
ground substance the gel-like material in which connective tissue cells and fibers are embedded.
substance-induced disorders a subgroup of the substance-related disorders comprising a variety of behavioral or psychological anomalies resulting from ingestion of or exposure to a drug of abuse, medication, or toxin. Included are substance intoxication, substance withdrawal, and other mental disorders such as dementia, mood disorder, and psychotic disorder when they are specifically caused by a substance. See also substance use disorders.
medullary substance
1. the white matter of the central nervous system, consisting of axons and their myelin sheaths.
2. the soft, marrow-like substance of the interior of such structures as bone, kidney, and adrenal gland.
müllerian inhibiting substance a glycoprotein produced by the Sertoli cells of the fetal testis that acts ipsilaterally in the male to suppress the müllerian ducts, consequently preventing development of the uterus and fallopian tubes, thus helping to control formation of the male phenotype.
substance P a peptide composed of 11 amino acids, present in nerve cells scattered throughout the body and in special endocrine cells in the gut; it increases the contractions of gastrointestinal smooth muscle and causes vasodilatation; it is one of the most potent vasoactive substances known, and it seems to be a sensory neurotransmitter involving pain, touch, and temperature.
perforated substance
1. anterior perforated substance, an area anterolateral to each optic tract, pierced by branches of the anterior and middle cerebral arteries.
2. posterior perforated substance, an area between the cerebral peduncles, pierced by branches of the posterior cerebral arteries.
pressor substance vasopressor (def. 2).
psychoactive substance (psychotropic substance) any chemical compound that affects the mind or mental processes, particularly a drug used therapeutically in psychiatry, or any of various other types of mind-altering substances such as drugs of abuse and some toxins. See also table at drug dependence. Called also psychoactive agent or drug and psychotropic agent or drug.

There are several different classes of psychoactive substances: antidepressants are used for the relief of symptoms of major depression. lithium is the most common agent used to treat manic episodes of bipolar disorder. antipsychotic agents (or major tranquilizers) are used for management of the manifestations of psychotic disorders such as schizophrenia. antianxiety agents (called also minor tranquilizers), such as diazepam (Valium), are used for relief of anxiety disorders. While none of these drugs can effect a cure, they can reduce the severity of symptoms and permit the patient to resume more normal activity.

Also included in the category of psychotropic drugs are many other substances that affect the mind but are not used to treat mental disorders, including stimulants such as caffeine, amphetamines, and cocaine; opiates; and hallucinogens.
substance-related disorders any of the mental disorders associated with excessive use of or exposure to psychoactive substances, including drugs of abuse, medications, and toxins. The group is divided into substance use disorders and substance-induced disorders, each of which is specified on the basis of etiology, such as alcohol use disorders. See also drug abuse and drug dependence.
slow-reacting substance of anaphylaxis SRS-A, an inflammatory agent released by mast cells in the anaphylactic reaction. It induces slow, prolonged contraction of certain smooth muscles and is an important mediator of allergic bronchial asthma.
threshold s's those substances in the blood, such as glucose, that are excreted when they reach their renal threshold.
transmitter substance neurotransmitter.
substance use disorders a subgroup of the substance-related disorders, in which psychoactive substance use or abuse repeatedly results in significantly adverse consequences. The group comprises substance abuse (see drug abuse) and substance dependence (see drug dependence); specific disorders or groups of disorders are named on the basis of etiology, e.g., alcohol use disorders, alcohol abuse, and alcohol dependence.
white substance white matter.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Synonym(s): substantia [TA], matter
[L. substantia, essence, material, fr. sub- sto, to stand under, be present]
Farlex Partner Medical Dictionary © Farlex 2012


Synonym(s): substantia [TA] , matter.
[L. substantia, essence, material, fr. sub-sto, to stand under, be present]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


A general term meaning any physical matter, or the nature of the matter of which something is made, which has, in recent years acquired a new sense. The term, in this restricted sense, is applied to any chemical, solid, liquid or gaseous, capable of affecting the state of the mind. A psychoactive material.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about substance

Q. What exactly is PPD? I heard it is a substance in hair color and that some women are allergic to it How can I know if I’m allergic to it?

A. That sounds nasty... so how can I know if i'm allergic to it or not?

Q. What are the bases of Chinese medicine? what substances make chinese medicine so effective according to people's opinion ...

A. good question...
because chinese medicine is a popular medicine and practiced in different rural areas of China- there is a lot of diversity between different methods. different feet maps for reflexology, different opinions on acupuncture points and such. but the general idea is the same. and believe it or not - the chinese medicine is actually a trial and error based method that developed over 4,000 years.
that is a lot of time to do trial and error...

Q. Can anybody tell me the point where I should be worried that I've become an alcoholoic? What is the definition of an alcoholist?

A. You truly have a great site here. Its got a lot of potential and can surely help many.

More discussions about substance
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References in periodicals archive ?
1.833(j) (sales that may give rise to suits under Section 16(b) of the Securities Exchange Act of 1934) and 1.83-3(k) (transfer restrictions under the pooling-of-interests accounting rule), a substantial risk of forfeiture may be established only through a service condition or a condition related to the purpose of the transfer; (2) in determining whether a substantial risk of forfeiture exists based on a condition related to the purpose of the transfer, both the likelihood that the forfeiture event will occur and the likelihood that the forfeiture will be enforced must be considered; and (3) except as specifically provided in Sec.
IRC Section 83 provides that if services are paid for with property, the person providing the services is required to include the fair market value of the property in gross income, but not until the first year in which his or her rights in the property are not subject to a "substantial risk of forfeiture."
* Substantial equivalency is a determination by a board of accountancy or its designee that the education, examination and experience requirements contained in another jurisdiction's statutes and administrative rules are comparable to or exceed the requirements specified in the act or that an individual CPA's education, examination and experience qualifications are comparable to or exceed the requirements contained in the UAA.
The Model Statute would require that taxpayers compile substantial state tax return information to be reported to each state in which the taxpayer files a tax return.
Under the "substantial equivalency" concept, which was developed by the AICPA and the National Association of State Boards of Accountancy as part of the Uniform Accountancy Act, CPAs with a valid license from a state with CPA licensing criteria that are "substantially equivalent" to those out-lined in the UAA can practice in another state without obtaining a license from that state.
What, and exactly how much, is of "comparable moral significance" in Singer's principle or is of "substantial significance" in Arthur's may not be relevant to HIV/AIDS when we consider how much the UN asks the affluent countries to give to the Global Health Fund.
According to Jerome Hesch, a professor at the University of Miami School of Law and Of Counsel to Greenberg Traurig, "in determining whether compensation payable to an employee who owns a significant amount of the stock of his/her employer corporation or its parent is subject to a substantial risk of forfeiture, the notice requires that there be taken into account the employee's relationship to other stock-holders and the extent of their control and possible loss of control by the corporation."
"The acquisition of 260 Cherry Hill Road represents an outstanding opportunity for tenants seeking a strategically located facility offering substantial, redundant power," stated Robert Martie, Senior Vice President & Regional Managing Director, Advance Realty Group.
Here Hirsch makes a substantial contribution to our growing understanding of the early process of deindustrialization.
The Ninth Circuit disagreed, holding that the district court properly applied the definition of disability, and there was substantial evidence to support the jury's finding that Hangarter was totally disabled.
This could be achieved, for example, with short reads that have no substantial information linking them to other reads.
* Recycler of the Year recognizes an individual in the construction and demolition recycling industry who has made superior and substantial contributions to his/her company or industry in achieving sound operating practices.

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