RGX-314 is a novel, one-time subretinal
gene therapy being developed for wet AMD and DR.
Regenxbio plans to evaluate RGX-314 using Clearside's SCS Microinjector for in-office, non-surgical delivery into the suprachoroidal space, while continuing to advance its RGX-314 subretinal
delivery program currently in development for wet AMD and DR.
injection has been gaining ground in the treatment of PVR, as it directly affects the resident cells & tissues in subretinal
(NYSE American:BTX) announced that it has dosed its first patient with the Orbit Subretinal
Delivery System (Orbit SDS) as well as with a new Thaw-and-Inject formulation of OpRegen , the company's retinal pigment epithelium (RPE) transplant therapy.
"Transplantation of human embryonic stem cell derived retinal tissue in the subretinal
space of immunodeficient rats with retinal degeneration (RD)" will be presented on April 30 by Igor Nasonkin of BioTime.
A one-time treatment, Luxturna is applied as a subretinal
Repeat injections were given to patients with intraretinal and/or subretinal
fluid in OCT.
A fundus examination of the left eye revealed multiple telangiectatic and irregular, dilated aneurysmal retinal vessels, exudative retinal detachment with deep, and extensive subretinal
lipid exudates with a well-defined macular edema.
B-scan ultrasound revealed vitreous opacity, retinal detachment, and subretinal
lesions in the right eye.
The fundus exhibits rapid appearance of multiple deep subretinal
yellow-white, flat lesions at the RPE/choriocapillaris level.
The Flt3 Inhibitor AC220 Significantly Reduces Subretinal
NV and the Ratio of TRD in VEGF-Overexpressing Mice.
SF0166 also demonstrated clinically significant biological activity, as assessed by a panel of three leading retinal physicians, in 9 of the 42 patients who completed the study evidenced by decreases in central retinal thickness and/or subretinal
fluid by spectral domain optical coherence tomography.