Omurilik, sinir kokleri, filum terminale (FT) ve her biri kollajenoz yapilardan olusan ve subpial
bag dokusu ile devamlilik gosteren ve aralikli olarak duraya yapisan dentat ligamanlar tarafindan askida tutulmaktadir (1).
demyelination in the cerebral cortex of multiple sclerosis patients.
Ependymal loss, subpial
necrotic lesions, loss of myelin, axonal swellings, necrosis, and reactive leukodiapedesis were seen.
Multiple Sclerosis and Epstein-Barr Virus - Subpial
Surgical interventions for the treatment of RSE include acute resective surgery and disconnection procedures such as multiple subpial
transection or corpus callosotomy .
The background cerebellar cortex was infiltrated by tumor cells, which also showed subpial
accumulation and extension to the subarachnoid spaces.
Demyelination was evaluated by Luxol fast blue staining and scored using a 6-point scale system: 0, normal white matter; 1, rare foci; 2, a few areas of demyelination; 3, confluent perivascular or subpial
demyelination; 4, massive perivascular and subpial
demyelination involving one half of the spinal cord with the presence of cellular infiltration in the CNS parenchyma; and 5, extensive perivascular and subpial
demyelination involving the whole cord section with the presence of cellular infiltration in the CNS parenchyma [12, 20].
In contrast to other tumors of the CNS, IGs demonstrate a particular propensity to infiltrate along preexisting structures, including white matter tracts, perivascular spaces, and subventricular and subpial
compartments, conforming to and exploiting a terrain that is ostensibly familiar to the neoplastic cell type.
(4,5,6,7) There is differing opinion as to whether GMH can also form due to neurons losing their way during migration, migrating in the wrong direction or migrating too far (into the subpial
space), and as to whether these heterotopic nests establish abnormal interconnections and exert abnormal trophic influences on surrounding tissue or whether only a limited number of axons exit these nests resulting in limited connectivity with other areas of the brain.
In the study by Magliozzi et al., a gradient of necroptosis and demyelination severity in the cortex under these leptomeningeal aggregates with maximal intensity in subpial
areas has been demonstrated .
The outermost layer of the cerebral wall, namely, the subpial
molecular zone, was the only stratum where these deposits could not be detected.