(10) However, within 3 to 4.5 hours after reaching peak testosterone levels, women reported a statistically significant increase in genital responsiveness, along with significant increases in genital arousal and subjective reports of "genital sensations" and "sexual lust." Administration of sublingual testosterone
(0.5 mg) increases the sensitivity of the brain to sexual cues, regardless of circulating plasma levels of testosterone.
forms are less efficient and need to be taken twice a day.
replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study.
Pharmacokinetics, bioefficacy, and safety of sublingual testosterone
cyclodextrin in hypogonadal men: comparison to testosterone enanthate--a clinical research center study.
Also under study are sublingual testosterone
cyclodextrin and buccal testosterone, which deliver high-peak serum testosterone levels.
(30) Using this as a guideline, physiologic doses of 7 to 10 mg/day of topical or sublingual testosterone
are typically sufficient to affect metabolic processes in males with measured low or suboptimal levels.