House dust mite
sublingual immunotherapy: Results of a US trial.
Caption: Figure 2:
Sublingual immunotherapy causes complex changes of the key genes of the interferon pathway.
Anaphylaxis to multiple pollen allergen
sublingual immunotherapy. Allergy 2007; 62: 567-8.
Of these,
sublingual immunotherapy (SLIT), in which liquid drops or allergen tablets are placed under the tongue for 1-2 minutes before being swallowed, and local nasal immunotherapy (LNIT), which involves spraying a solution or dry powder into the nostril, were found to be viable alternatives.
The latest form of this therapy is called
sublingual immunotherapy (SLIT), which has been used for the past 20 years in Europe.
But over a 3-year study period, the investigators observed a significant reduction in nasal obstruction, itching and cough, and a decreased need for symptom-relief medications in patients treated with standard medications plus
sublingual immunotherapy, compared with those treated only with for allergic rhinitis and asthma.
We have reviewed the history of
sublingual immunotherapy, a very old treatment modality that is being used extensively in Europe for the last 20 years, and interest in its use is growing in the US.
(A PubMed search was done for treatment of asthma with
sublingual immunotherapy in the US; no articles were found).
Therefore,
sublingual immunotherapy even when used at a very high dose, was about half as effective as subcutaneous immunotherapy.
--
Sublingual immunotherapy, widely used for allergy control and prevention in Europe and South America, is beginning to draw the attention of mainstream allergists in the United States, Dr.
San Antonio -- Adults with dust-mite allergy respond better to
sublingual immunotherapy compared with standard allergy medications, according to Italian researchers.