House dust mite sublingual immunotherapy
: Results of a US trial.
Caption: Figure 2: Sublingual immunotherapy
causes complex changes of the key genes of the interferon pathway.
Anaphylaxis to multiple pollen allergen sublingual immunotherapy
. Allergy 2007; 62: 567-8.
Of these, sublingual immunotherapy
(SLIT), in which liquid drops or allergen tablets are placed under the tongue for 1-2 minutes before being swallowed, and local nasal immunotherapy (LNIT), which involves spraying a solution or dry powder into the nostril, were found to be viable alternatives.
The latest form of this therapy is called sublingual immunotherapy
(SLIT), which has been used for the past 20 years in Europe.
But over a 3-year study period, the investigators observed a significant reduction in nasal obstruction, itching and cough, and a decreased need for symptom-relief medications in patients treated with standard medications plus sublingual immunotherapy
, compared with those treated only with for allergic rhinitis and asthma.
We have reviewed the history of sublingual immunotherapy
, a very old treatment modality that is being used extensively in Europe for the last 20 years, and interest in its use is growing in the US.
(A PubMed search was done for treatment of asthma with sublingual immunotherapy
in the US; no articles were found).
Therefore, sublingual immunotherapy
even when used at a very high dose, was about half as effective as subcutaneous immunotherapy.
-- Sublingual immunotherapy
, widely used for allergy control and prevention in Europe and South America, is beginning to draw the attention of mainstream allergists in the United States, Dr.
San Antonio -- Adults with dust-mite allergy respond better to sublingual immunotherapy
compared with standard allergy medications, according to Italian researchers.