We and others have previously argued that 5-[HT.sub.2A] and 5-[HT.sub.7] receptors are important in the initiation and control of locomotion [3-12], and that these receptors mediate hindlimb locomotor recovery produced in paraplegic animals after replacement of 5-HT neurons into the sublesional
spinal cord by grafts of fetal brainstem [10,13].
He, "Treatment with hydrogen sulfide attenuates sublesional
skeletal deterioration following motor complete spinal cord injury in rats," Osteoporosis International, vol.
skeletal muscle paralysis and sedentary lifestyle behaviors result in loss of lean tissue mass and a gain in adiposity that dramatically decreases in the daily energy expenditure (3).
Nevertheless, other results have been conflicting: numerous animal model investigations have revealed malunion, delayed union, or non-union sublesional
limb fractures in mice with SCI [18,19], and osteoporosis in persons with SCI will increase the risks of lower limb fractures .
Indice histologico 0 1 2 3 Proliferacao vascular 0 1-5 5-15 >15 Celulas mononucleares 0 <50 50-100 >100 Celulas polimorfonucleares 0 <50 50-100 >100 Proliferacao Fibroblastica 0 <50 50-100 >100 Colagenizacao (a) 0 <10 10-30 >30 Re-epitelizacao (b) 0 <1 1-2 >2 Foliculos pilosos (c) 0 <30% 30-60% >60% Queratina (d) 0 lx 2-3x >3x (a) avaliacao feita na regiao sublesional
; (b) relacao feita atraves da visualizacao de um campo de 400x; (c) porcentagem estabelecida em relacao ao tamanho do bulbo do foliculo piloso; (d) proporcao feita em relacao ao tamanho da lamina basal do epitelio.
Supralesional and sublesional
bone mineral density in spinal cord injured patients.
Intensive exercise or standing regimens may partially prevent bone loss in the femoral shaft but not at the proximal hip, while functional electrical stimulation [7,13-15] and pharmacological agents (etidronate, alendronate) are reported to be ineffective in patients with SCI [16-17], probably because of an exorbitant sublesional
bone turnover and osteoclastic activity at all the resorption pits .
However, in some studies osteoporosis in sublesional
areas has been shown shortly after SCI by using the DEXA technique (6,7).
Any existing or new lesions were successfully treated with sublesional
triamcinolone injections and intensive topical therapy.
Although we found an absence of traced RtST axons in the sublesional
spinal cord, as little as 5% sparing in the ventrolateral white matter can support recovery of up to a score of 8 on the BBB scale (rhythmic movements of the two hindlimbs) .