Looking at three subregions - the cornu ammonis (CA) 1, CA3/dentate gyrus and
subiculum - they found that the first two expanded with age, with the most pronounced growth in the right hippocampus.
2008) found hippocampal atrophy in the CA1, CA2, and CA3 regions and the
subiculum and presubiculum in patients with DLB, but not in patients with AD.
If the section includes parahippocampal gyrus, the Thal phase of amyloid deposition can easily be determined, as amyloid plaques appear early in neocortex (phase 1), later in CA1 and the
subiculum (phase 2), still later in the fascia dentata (phase 3), then in CA4 (phase 4), and finally in cerebellum and brainstem (phase 5).
The effects of hippocampal damage on psychogenic HPA axis stress responses can be localized to the ventral
subiculum (vSUB), the main subcortical output of the ventral hippocampus (Herman et al.
The present study was undertaken to count total number of neurons in CA1-4 sectors and the
subiculum of the dog hippocampus and investigate the presence of the paw, sex and right/left differences.
Effects of lesions to amygdala, ventral
subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implications for limbic--striatal interactions.
The hippocampus, however, is not a homogeneous structure but consists of several histologically and functionally distinct but tightly interconnected subfields: the
subiculum with the subdivisions presubiculum, parasubiculum, and
subiculum proper; the four cornu ammonis sectors (CA1-4); and the dentate gyrus (DG) [196].
Combined lesions of hippocampus and
subiculum do not produce deficits in a nonspatial social olfactory memory task.
But when the MCI brains were compared with EAD brains, the plaques only increased significantly in the amygdala and
subiculum.
We noticed [Alzheimer's-]related neuronal loss in two subdivisions that normally lose neurons with age, the hilus and the
subiculum, but also noticed neuronal loss in CA1, a region in which there is no evidence of normal age-related loss," they report.
The researchers targeted a key player in the hippocampal "learning system," which includes the hippocampus itself, the
subiculum (the major output structure connected to the cortex, the self-aware "thinking" part of the brain), and the adjacent entorhinal cortex.
NFAs are observed mostly in the superior cortex, lateral and inferior cerebral cortices, at the level of the superior and the inferior hippocampus also the striatum pyrimidale
subiculum, superior and inferior segments of hippocampus (38,39).
