Additionally, abnormalities were found in the hippocampus, subiculum
, entorhinal cortex, septal nuclei, mamillary body, selected nuclei of the amygdala, neocerebellar cortex, roof nuclei of the cerebellum, and inferior olivary nucleus (Bauman & Kemper, 2005).
Pyramidal Apical G (26) neuron dendrites Kolluri n.d.
In MTL subregional analysis, there were inverse correlations for parahippocampal (P = 0.007), entorhinal (P = 0.05), and cortical and subiculum
(P = 0.04) thicknesses with hours of sitting per day.
Polcari, "Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum
," Proceedings of the National Academy of Sciences of the United States of America, vol.
Moreover, pathological changes such as amyloid plaques and agminated tau protein in regions of entorhinal cortex, parahippocampal gyrus, and subiculum
in the medial temporal lobes can be tracked in MCI as well, although it may be not that severe compared with AD .
(11,16) Pathologically, HS-aging is defined by neuron loss and gliosis in the hippocampal sector CA1 and subiculum
that is out of proportion to the burden of AD neuropathologies.
As previously described in the literature, HIA is the angle between the line connecting the medial superior margin of the subiculum
with the lateral margin of the cornu ammonis and the vertical midline of the cerebral hemisphere (Figs.
The hippocampal formation consists of the dentate gyrus, cornu ammonis (CA) regions, and the subiculum
. The dentate gyrus receives afferent connections from the entorhinal cortex, which act as an input region.
Price, "Projections from the amygdaloid complex and adjacent olfactory structures to the entorhinal cortex and to the subiculum
in the rat and cat, "Journal of Comparative Neurology, vol.
The transitional area between the CA1 region and the subiculum
was also CA1led distal portion of CA1 region in several studies [25, 26] or prosubiculum in others [18, 23, 27].
While the NFTs arise first in the locus coeruleus, entorhinal cortex and limbic brain areas such as the subiculum
of the hippocampal formation, the amygdala, thalamus, and claustrum, and then spread to interconnected neocortical regions (18,24).