1) New cells in the dentate gyrus divide along the subgranular
zone during early development, migrate into the granule cell layer, and become neurons in shape (morphology) and gene expression (phenotype).
There was good graft survival, with extensive migration of BrdU-positive cells either specifically within the subgranular
layer of the dentate gyrus (DG); or throughout the striatum, in particular toward the globus pallidus.
Neurogenesis is the production of new neurons and continues throughout the adult mammalian lifespan in the subventricular zone of the lateral ventricles and the subgranular
zone of the hippocampal dentate gyms (DG).
Jude Children's Research Hospital focused on a small region of the hippocampus known as the dentate gyrus, a brain structure needed for memory and learning that is home to the subgranular
zone where the neural stem cells destined to become granule cells are housed.
The most active areas of adult neurogenesis are the subventricular zone (SVZ) of the lateral ventricles and the subgranular
zone (SGZ) of the hippocampal dentate gyms.
The most active neurogenesis occurs in the subventricular zone (SVZ) of the lateral ventricles and the subgranular
zone (SGZ) of the hippocampus (3, 4).