choroidal thickness measurements with enhanced depth imaging optical coherence tomography in patients with nanophthalmos," British Journal of Ophthalmology, vol.
(33,34) However, although there is also evidence of efficacy in the treatment of subfoveal
lesions, thermal laser treatment has largely been avoided in patients with this manifestation of wet AMD due to the risk of immediate laser-induced visual loss.32 Furthermore, there is evidence to suggest that the treatment is only effective in classic neovascular lesions.
Among the liposomal drugs, Visudyne[R], a conventional liposome containing vertoporfin, is the first liposomal drug developed for the treatment of subfoveal
choroidal neovascularization due to macular degeneration, pathological myopia, chronic central serous chorioretinopathy and choroidal hemangioma.
The CNVMs may be classified according to their location as subfoveal
, juxtafoveal or extrafoveal.
HARBOR (6) is a Phase 3 trial in which the 2-year efficacy results of two different doses of ranibizumab (0.5 mg and 2 mg) with two different administration regimens (monthly/PRN) were evaluated in treatment-naive wet AMD patients with active subfoveal
 further demonstrated that subfoveal
blood flow is reduced in patients with RP and correlates with central cone function, as measured by laser Doppler flowmetry and assessed by focal electroretinograms (FERGs), respectively.
Brown et al., "Twelve-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal
neovascular age-related macular degeneration," Ophthalmology, vol.
Macular OCT scans were performed using Topcon 3D OCT-2000 System; CMT measurements and featured macular morphology (subfoveal
exudate plaques, the presence of serous macular detachment and RPE changes) were assessed at baseline and every 4-8 weeks after each injection by two retina specialists.
Full thickness of the outer nuclear layer (ONL), photoreceptor ellipsoid zone (EZ; distance between the lower border of the external limiting membrane and the anterior surface of the RPE), SRF, and central retinal thickness (CRT) were manually drawn at the subfoveal
point by 2 retinal specialists (J.L.
The PCV lesions on ICGA had totally resolved but a small area of subfoveal
atrophy developed during the follow-up period (Figure 2f).
We also manually measured the subfoveal
choroid thickness (SFCT) by using the enhanced depth image (EDI) OCT image .
Immunohistochemical characterization of surgically removed subfoveal