Effect of shear rate on platelet interaction with subendothelium
in citrated and native blood.
Von Willebrand Factor (VWF) is a polymeric plasma glycoprotein comprising multiple 250-kDa subunits that facilitates platelet adhesion to the vessel wall by linking platelet membrane receptors to the subendothelium
and is the cornerstone of platelet--endothelial interaction.
Occasionally, the luminal surface of the plaques was lined by vacuolated spindle cells and presumptive endothelial cells, and the subendothelium
contained foam cells interpreted as macrophages (Fig 3D).
When platelets come into contact with collagen or von Wilebrand factor in the subendothelium
, they bind to fibres and become activated (fig 2).
Subsequently, the leukocytes and tumor cells firmly adhere to endothelium by interaction with VCAM-1 and ICAM-1 after which they permeate into the subendothelium
1987) and, more important, PS-exposing MVs provide sites for adhesion of platelets and neutrophils by localizing at the subendothelium
, indicating that [Hg.
Histologically, in addition to the interstitial lymphoplasmacytic infiltrate, areas of arteritis and venulitis, consisting of permeation of the subendothelium
by numerous lymphocytes and plasma cells, were accompanied by narrowing or obliteration of the vascular lumina.
This hypercholesterolemia causes diffuse cholesterol deposition in the subendothelium
and principally mimics lipid storage diseases.
Platelets fail to adhere to exposed subendothelium
resulting in bleeding.
RFVIIa combines with tissue factor (TF) in the subendothelium
of damaged blood vessels to create a thrombin burst1.
It is felt that once the complexes are deposited in the subendothelium
and mesangium, there is activation of the complement system leading to cellular proliferation and mononuclear cell infiltration.
These small molecules then freely diffuse into the renal tubules and the subendothelium