Pathologic diagnosis was based on the presence of all 3 of the following histologic signs: widening of subendothelium
with myxoid degeneration, intraluminal thrombus formation, and fibrinoid necrosis of terminal arterioles.
Increased TG induces thrombosis associated with neutrophil adhesion during the inflammatory response initiated when injury to a vessel wall exposes the blood to tissue factor in the subendothelium
(Rau et al.
The other possible mechanisms are chemical arteritis and tissue destruction of endothelium, subendothelium
, or muscle layers of vessel (1, 6, 7).
22) Anemia could further worsen the bleeding disorder because red cells release ADP and facilitate platelets contacting with subendothelium
at the damage site.
Migration of monocytes into the subendothelium
is the initial step of inflammation and atherosclerotic plaque formation, which plays a key role in the atherosclerotic plaque formation.
Nevertheless, one should not ignore any damage to the endothelium and subendothelium
by pressure of convex ends of intracoronary shunts (especially when too big shuts are used).
Atherosclerosis begins as a disease of the subendothelium
and the vessel wall in direct response to the foods and inflammatory milieu that we create.
The HDL cholesterol is a lipoprotein that carries out the reverse cholesterol transport, removing the excess of free cholesterol not only from cell membranes but also from the subendothelium
and transporting it to the liver to be degraded (Shils et al.
This condition enhances fatty streaks formation because lipid migration into the subendothelium
is greater than its removal from the arterial wall.
Upon vascular damage subendothelium
macromolecules such as collagen thrombin ADP serotonin (5-HT) and thromboxane A2 (TxA2) are exposed or secreted at the site of damage and platelets adhere to exposed subendothelium
which are activated and leads to hemostasis (Hubbard et al.
In 13 cm CVRL foetus the thin layer of subendothelium
was observed with large number of differentiating Purkinje fibres.
Von Willebrand Factor (VWF) is a polymeric plasma glycoprotein comprising multiple 250-kDa subunits that facilitates platelet adhesion to the vessel wall by linking platelet membrane receptors to the subendothelium
and is the cornerstone of platelet--endothelial interaction.