subcutaneous injection

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2. the forcing of a liquid into a part, as into the subcutaneous tissues, the vascular tree, or an organ.
3. a substance so forced or administered; in pharmacy, a solution of a medicament suitable for injection.

Immunizing substances, or inoculations, are generally given by injection. Some medicines cannot be given by mouth because chemical action of the enzymes and digestive fluids would change or reduce their effectiveness, or because they would be removed from the body too quickly to have any effect. Occasionally a medication is injected so that it will act more quickly. In addition to the most common types of injections described below, injections are sometimes made into arteries, bone marrow, the spine, the sternum, the pleural space of the chest region, the peritoneal cavity, and joint spaces. In sudden heart failure, heart-stimulating drugs may be injected directly into the heart (intracardiac injection).
Sites for injections. A, subcutaneous injection sites. B, intramuscular injection site for children in the vastus lateralis muscle. C, D, and E, intramuscular injection sites for adults: C, deltoid muscle injection site. D, injection site in the buttock (dorsogluteal site). E, injection site in the anterolateral thigh (ventrogluteal site).
hypodermic injection subcutaneous injection.
intracutaneous injection intradermal injection.
intracytoplasmic sperm injection (ICSI) a micromanipulation technique used in male factor infertility; a single spermatocyte is inserted into an oocyte by micropuncture.
intradermal injection injection of small amounts of material into the corium or substance of the skin, done in diagnostic procedures and in administration of regional anesthetics, as well as in treatment procedures. In certain allergy tests, the allergen is injected intracutaneously. These injections are given in an area where the skin and hair are sparse, usually on the inner part of the forearm. A 25-gauge needle, about 1 cm long, is usually used and is inserted at a 10- to 15-degree angle to the skin.
intramuscular injection injection into the substance of a muscle, usually the muscle of the upper arm, thigh, or buttock. Intramuscular injections are given when the substance is to be absorbed quickly. They should be given with extreme care, especially in the buttock, because the sciatic nerve may be injured or a large blood vessel may be entered if the injection is not made correctly into the upper, outer quadrant of the buttock. The deltoid muscle at the shoulder is also used, but less commonly than the gluteus muscle of the buttock; care must be taken to insert the needle in the center, 2 cm below the acromion.

Injections into the anterolateral aspect of the thigh are considered the safest because there is less danger of damage to a major blood vessel or nerve. The area permits multiple injections, is more accessible, and is easier to stabilize, particularly in pediatric patients or others who are restless and uncooperative. The vastus lateralis muscle is located by identifying the trochanter and the side of the knee cap and then drawing a visual line between the two. The distance is then divided into thirds and the needle inserted into the area identified as the middle third.

The needle should be long enough to insure that the medication is injected deep into the muscle tissue. The gauge of the needle depends on the viscosity of the fluid being injected. As a general rule, not more than 5 ml is given in an intramuscular injection for an adult. The maximum for an infant is 0.5 ml, and the injection is made into the vastus lateralis muscle. The needle is inserted at a 90-degree angle to the skin. When the gluteus maximus muscle is the site chosen for the injection, the patient should be in a prone position with the toes turned in if possible. This position relaxes the muscle and makes the injection less painful.
intrathecal injection injection of a substance through the theca of the spinal cord into the subarachnoid space. Patients receiving intrathecal chemotherapy for metastatic malignancy of the central nervous system should maintain a flat or Trendelenburg position for one hour after treatment to achieve optimum distribution of the drug.
intravenous injection an injection made into a vein. Intravenous injections are used when rapid absorption is called for, when fluid cannot be taken by mouth, or when the substance to be administered is too irritating to be injected into the skin or muscles. In certain diagnostic tests and x-ray examinations a drug or dye may be administered intravenously. (See also intravenous infusion.)
jet injection injection of a drug in solution through the intact skin by an extremely fine jet of the solution under high pressure.
subcutaneous injection injection made into the subcutaneous tissues. Although usually fluid medications are injected, occasionally solid materials such as steroid hormones may be injected in small, slowly absorbed pellets to prolong their effect. Subcutaneous injections may be given wherever there is subcutaneous tissue, usually in the upper outer arm or thigh. A 25-gauge needle about 2 cm long is usually used, held at a 45-degree angle to the skin, and the amount injected should not exceed 2 ml in an adult. Subcutaneous insulin injections may be given at a 90-degree angle with an insulin syringe. Called also hypodermic injection.
Angle of needle insertion for administering a subcutaneous injection. From Lammon et al., 1995.
Z-track injection see z-track injection.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

sub·cu·ta·ne·ous in·jec·tion

(sŭb'kyū-tā'nē-ŭs in-jek'shŭn)
Injection of fluid into loose connective tissue below the dermis. Absorption is slower than that of intramuscular injection. Common sites include outer posterior side of arm and abdomen. Usually only 0.5-1 mL fluid is given by this method.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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subcutaneous injection

Injection beneath the skin. Typical sites include the abdomen, upper or outer arm, and the thigh.
See: illustration
See also: injection
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
This continues to be the standard of care when it comes to intravenous, intramuscular and infusion-based therapies, but not for subcutaneous injections. What started as a burden for patients with diabetes, multiple daily subcutaneous injections, has evolved into a manageable dosing strategy for a variety of medical conditions.
Subcutaneous injections can be self-administered in other parts of the body and cause less pain.
Inhaled delivery will not eliminate the need for the nighttime subcutaneous injection, but many patients find the inhaled option to be a much more acceptable way to take care of the preprandial doses.
C Copaxone (copolymer 1) is taken every day, using the shallow subcutaneous injection method, which can be done at home by the person with MS or by a family member following brief training.
In addition to the new indication, Humira Pre-filled Syringe 20 mg/0.4 mL for Subcutaneous Injection, a new formulation for patients with a low body weight, also received approval from the MHLW.
Pharmacokinetic (PK) profiles resulting from sMTS delivery of a variety of molecules showed comparable performance to administration of the drug by subcutaneous injection. "Our more recent data show effective delivery of large molecules, like proteins, with sMTS delivery efficiency matching subcutaneous delivery.
HAVEN 2 was a single-arm, multicentre, open-label, global Phase III study that investigated the safety, efficacy and pharmacokinetics of once-weekly subcutaneous injection of the drug in paediatric patients with haemophilia A with inhibitors to factor VIII.
(Nasdaq: ATRX), Fort Collins, Colo., has received approval from the FDA for Eligard(TM) 7.5 mg (formerly Leuprogel One-Month Depot), leuprolide acetate for subcutaneous injection for treatment of advanced prostate cancer.
Other FDA-approved treatments for the chronic treatment of moderately to severely active ulcerative colitis must be administered through an intravenous infusion or subcutaneous injection. "New treatments are needed for patients with moderately to severely active ulcerative colitis," said Julie Beitz, M.D., director of the Office of Drug Evaluation III in FDA's Center for Drug Evaluation and Research.
Roche (SIX: RO, ROG; OTCQX: RHHBY), a Swiss-multinational healthcare company, today announced that the US Food and Drug Administration (FDA) has approved Actemra(R)/RoActemra(R) (tocilizumab) subcutaneous injection for the treatment of GCA, a chronic and severe autoimmune condition.

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