Los trabajos de preparacion de los cerebros realizados siguiendo estrictamente la tecnica original de Klingler (Ludwig & Klingler) han permitido la identificacion de estructuras profundas como las radiaciones opticas, la capsula interna, el tracto subcallosal
, las partes del fasciculo longitudinal superior y otros.
area containing the medial prefrontal (dorsal and ventral) and anterior cingulate cortices has been implicated in tinnitus pathophysiology according to neuroimaging studies, making this area a potential target for tinnitus treatment with rTMS [4, 5].
In this surgical technique, stimulatory VNS-like electrodes are placed through stereotactic methods in specified brain areas (such as the subcallosal
cingulated gyrus, nucleus accumbens, ventral capsule/ventral striatum, inferior thalamic peduncle, habenula/lateral habenula, and the medial forebrain bundle) (1, 33).
Electrodes have been implanted in the subcallosal
cingulate gyrus, inferior thalamic peduncle, ventral capsule/ventral striatum, superolateral branch of the medial forebrain bundle (MFB), and nucleus accumbens.
In one of these studies, the higher availability of opioid receptors was detected in the caudate nucleus, NAc and subcallosal
area, insula, and PAG in chronic pain due to osteoarthritis and rheumatoid arthritis when compared to healthy subjects.
Functional magnetic resonance imaging (fMRI) studies have shown that binge drinking is associated with changes in activation (assassed by the blood-oxygen-level-dependent signal (BOLD)) in the resting brain including the subcallosal
cortex (SCC), left temporal fusiform cortex (TFC), and left inferior temporal gyrus (ITG), which is involved in the reward brain network, visual recognition of the emotions, and memory, respectively .
(2014) 82 total patients Nonresponse (unmedicated associated with prior to starting pretreatment trial) hyperactivity in the subcallosal
cingulate and in the superior temporal sulcus PET 12/24 weeks of CBT and/or antidepressant (escitalopram) treatment Ritcheyet al.
Gray, "NPY mediates basal and seizure-induced proliferation in the subcallosal
zone," Neuroreport, vol.
The stimulation targets selected in these clinical studies included the subcallosal
cingulate, nucleus accumbens (NAC), and the habenula.
Deep brain stimulation of the subcallosal
cingulate area appears to significantly decrease the symptoms of treatment-resistant depression.
Researchers initially chose the subcallosal
cingulate gyrus because it is involved in processing the emotion of acute sadness.
Jude Medical-sponsored study were implanted with the Libra DBS system which delivers mild pulses of current from a device implanted near the collarbone to small electrical leads placed in the subcallosal
cingulate (SCC) area of the brain, a structure within Brodmann Area 25.