Strontium ranelate (SR), which has been demonstrated as an effective anti-osteoporosis remedy, has the potential to reduce the incidence of spinal and hip fracture in postmenopausal women (20).
In several double-blind trials, treatment with strontium in doses of 170-680 mg per day (as
strontium ranelate) for two to five years significantly increased bone mineral density of the hip and spine and significantly reduced the incidence of fractures by 16-49%, compared with placebo, in postmenopausal women with osteoporosis.
Saltel, and P Jurdic, "Dual effect of
strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro," Bone, vol.
The objective of this paper is the analysis of the effectiveness of pharmacological correction of experimental osteoporosis with a combination of rosuvastatin with L-norvaline compared with drugs
strontium ranelate (Bivalos) and Calcium D3 Nycomed.
The objective of this study was to compare the Primary and Secondary stability of immediate implant placement with Alveolar Ridge Augmentation (ARA) and
Strontium Ranelate (SR) as aids to enhance the stability using Resonance Frequency Analysis (RFA).
Strontium ranelate has been proven to favor bone healing by both increasing new bone formation and reducing bone resorption [15-18].
"The Europeans use
strontium ranelate (Protelos), which is not approved here.
I had read the research on
strontium ranelate and was told by a friend of mine, a PhD osteoporosis researcher, that he thought at the 680 mg of
strontium ranelate that was being used in Europe, we would ultimately hear of associated side effects.
The investigators performed an ancillary study of patients enrolled in the phase III, randomized
Strontium Ranelate in Knee Osteoarthritis (SEKOIA) trial, in which assessments included hand x-rays and hand symptoms.
Analgesics, calcium and vitamin D, and
strontium ranelate were prescribed.
Strontium ranelate is a developed drug that has been shown to be effective in reducing the risk of vertebral and hip fractures in postmenopausal women with osteoporosis.