streptozotocin


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streptozotocin

(strĕp′tə-zŏt′ə-sĭn)
n.
An antibiotic, C8H15N3O7, produced by an actinomycete (Streptomyces achromogenes), used primarily to treat pancreatic tumors affecting the Islets of Langerhans. Also called streptozocin.

streptozotocin

Oncology An alkylating nitrosurea derivative used to treat lymphomas and other CA Adverse effects Renal tubular dysfunction, glycosuria, hypoglycemia
References in periodicals archive ?
The other 30 rats were subjected to fasting for 12 h and were then intravenously injected with freshly prepared streptozotocin (65 mg/kg body weight) in a 0.1 mol/L citrate buffer (pH 4.5).
Elevated activities of liver marker enzymes like AST, ALT and ALP in serum of diabetic control rats is an indication of hepatotoxic effects of streptozotocin (Navarro et al.
in their study where oral administration of tocotrienol- rich fractions (200 mg/kg body weight) given daily for eight weeks to streptozotocin induced diabetic rats, on electron microscopy, showed disruption in normal morphology of thoracic aorta22.
Carboxy-PTIO (sodium salt) was obtained from the Cayman Chemical Company, Ann Arbor, MI.4-OH tempol and streptozotocin, HEPES and Phosphate Buffered Saline (PBS) were purchased from Sigma/Aldrich Chemical Company, St.
Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotocin contributes to islet cell DNA damage.
The effects of myoinositol on the autonomic neuropathy in the streptozotocin diabetic rat--a freeze fracture study.
After Streptozotocin administration, on day 3 the blood glucose level was markedly increased (274[+ or -]11.9 mg/dl) as compare to control(99.7[+ or -]17.7 mg/dl).
Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet.
Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats.
(2013) reported that wheatgrass extract demonstrated significant anti-hyperglycemic, hypo-lipidemic and antioxidant activity in diabetic rats induced with streptozotocin. Rana et al.
Streptozotocin, an antibiotic extracted from Streptomyces achromogenes and commercially available today in a highly purified form, is a common agent used for inducing experimental diabetes.
officinale was reported in streptozotocin induced diabetic rats.