streptozotocin


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streptozotocin

(strĕp′tə-zŏt′ə-sĭn)
n.
An antibiotic, C8H15N3O7, produced by an actinomycete (Streptomyces achromogenes), used primarily to treat pancreatic tumors affecting the Islets of Langerhans. Also called streptozocin.

streptozotocin

Oncology An alkylating nitrosurea derivative used to treat lymphomas and other CA Adverse effects Renal tubular dysfunction, glycosuria, hypoglycemia

streptozocin, streptozotocin

a nitrosurea compound with antineoplastic activity, derived from Streptomyces achromogenes; used principally in the treatment of islet-cell tumors of the pancreas.
References in periodicals archive ?
Elevated activities of liver marker enzymes like AST, ALT and ALP in serum of diabetic control rats is an indication of hepatotoxic effects of streptozotocin (Navarro et al.
On the other hand, it is shown that 8 weeks of endurance training had decreased thiobarbituric acid reactive substances levels in kidney at rest and after exercise in streptozotocin induced diabetic rats.
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthatase in pancreatic islets.
Streptozotocin (STZ), glibenclamide (GB), tolbutamide (TB), collagenase V and bovine serum albumin (BSA) were obtained from Sigma (St.
Antidiabetic activity of some herbal plants in streptozotocin induced diabetic albino rats, Pak.
Concurrently, in a series of animal models, normal, streptozotocin (STZ) diabetic and sand rats were used in the inverted sac model to determine the mechanism through which OLE affected starch digestion and absorption.
We injected 50mg/kg body weight (BW) streptozotocin (STZ) intraperitoneally (i.
GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice.
Min and his colleagues induced hyperglycemia in adult mice by injecting them with streptozotocin, a toxin that poisons insulin-producing beta cells.
Induction of diabetes in rats: Rats (n=40) were fed a high fat diet for 2 months and diabetes was induced by a single intraperitoneal injection of freshly prepared streptozotocin (STZ, 30 or 50 mg/kg bw) (Sigma, St.
Thus, in this study we induced hypoinsulinemia using streptozotocin in growing lambs to investigate changes in appetite, growth parameters, carcass composition and other related blood metabolites.
Researchers at the Bishop Heber College in Tamil Nadu recently undertook a study into this plant and its effects on the blood sugar levels of both normal and streptozotocin (STZ) induced diabetic rats.