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an antitumor antibiotic derived from Streptomyces achromogenes, now produced synthetically. It contains a nitrosourea group linked to a methyl group and a glucosamine moiety and acts as an alkylating agent to inhibit DNA synthesis, and also as an inhibitor of enzymes involved in gluconeogenesis; used primarily for treatment of islet cell carcinoma of the pancreas and other endocrine tumors including gastrinomas associated with zollinger-ellison syndrome and glucagon-secreting alpha cell tumors of the pancreas.
streptozocin/strep·to·zo·cin/ (-zo´sin) an antineoplastic antibiotic derived from Streptomyces achromogenes; used principally in the treatment of islet cell and other tumors of the pancreas.
an antineoplastic used in the treatment of neoplasms, including metastatic islet cell tumors of the pancreas. It is an antibiotic substance from Streptomyces acromogenes.
a nitrosurea compound with antineoplastic activity, derived from Streptomyces achromogenes; used principally in the treatment of islet-cell tumors of the pancreas.