streptozocin


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streptozocin

 [strep″to-zo´sin]
an antitumor antibiotic derived from Streptomyces achromogenes, now produced synthetically. It contains a nitrosourea group linked to a methyl group and a glucosamine moiety and acts as an alkylating agent to inhibit DNA synthesis, and also as an inhibitor of enzymes involved in gluconeogenesis; used primarily for treatment of islet cell carcinoma of the pancreas and other endocrine tumors including gastrinomas associated with zollinger-ellison syndrome and glucagon-secreting alpha cell tumors of the pancreas.

streptozocin

/strep·to·zo·cin/ (-zo´sin) an antineoplastic antibiotic derived from Streptomyces achromogenes; used principally in the treatment of islet cell and other tumors of the pancreas.

streptozocin

(strĕp′tə-zō′sĭn)

streptozocin

[strep′təzō′sin]
an antineoplastic used in the treatment of neoplasms, including metastatic islet cell tumors of the pancreas. It is an antibiotic substance from Streptomyces acromogenes.

streptozocin, streptozotocin

a nitrosurea compound with antineoplastic activity, derived from Streptomyces achromogenes; used principally in the treatment of islet-cell tumors of the pancreas.
References in periodicals archive ?
A model resembling type 2 diabetes in humans with a combination of insulin resistance and insulin deficiency was developed with administration of high fat diet consisted of 58% fat, 25% protein and 17% carbohydrate, as a percentage of total kcal7 for two weeks prior to streptozocin injection.
Male albino wistar rats were given intraperitoneal injection of Streptozocin to make them diabetic.
33) List Assigned number Arsenic trioxide (Trisenox[R]) P P012 Cyclophosphamide (Cytoxan[R]) U U058 Chlorambucil (Leukeran[R]) U U 035 Daunorubicin (Daunomycin[R], Cerubidine[R]) U U059 Diethylstilbestrol U U089 Melphalan (Alkeran[R]) U U150 Mitomycin (Mitomycin C[R], Mutamycin[R]) U U010 Streptozocin (Zanosar[R], Streptozocin[R]) U U206 Uracil Mustard (Uramustine[R]) U U237 * U.
2] Streptozocin Mitomycin Mitoxantrone Paclitaxel Moderate (30%-90% frequency Minimal (< 10% frequency of emesis) of emesis) Carboplatin Bevacizumab Cyclophosphamide < Bleomycin 1,500 mg/ [m.
Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat.
Melatonin protects against streptozocin, but not interleukin-1B-induced damage of rodent pancreatic B-cells.
Examples of nitrosureas are Carmustine, Lomustine and Streptozocin.
Combination treatment with streptozocin and doxorubicin is the favored first-line therapy in advanced disease.
Drugs that might interfere with the results of monitoring tests Antineoplastic drugs Other drugs Azacitidine Atropine Busulfan Chloral hydrate Chlorambucil Chlordiazepoxide Cisplatin Chlorpromazine Cyclophosphamide Cimetidine Cytarabine Diazepam Dacarbazine Dobutamine Dibromodulcitol Dopamine Estramustine Ephedrine Floxuridine Fentanyl Fludarabine Haloperidol Fluorouracil Hydroxyzine Ifosfamide Meperidine Lomustine Metoclopramide Mercaptopurine Midazolam Methotrexate Morphine Streptozocin Pentobarbital Thiopeta Phenylephrine Prochlorperazine Promethazine Ranitidine Scopolamine Secobarbital Temazepam
Chemotherapeutic agents, including cyclophosphamide, doxorubicin, 5-fluorouracil, dacarbazine, cisplatin, estramustine, and streptozocin, alone or in combination, have produced disappointing overall response rates of approximately 30% (in those with mostly stable disease, with few complete or partial responses), with median survivals of 26 to 33 weeks.
Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism.