Assessments of anti-diabetic activity in
streptozocin induced diabetic rats
Fluorouracil, doxorubicin, and
streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas.
For this study, mouse model resembling type 2 diabetes was made by giving
streptozocin injection with prior administration of high fat diet consisting of 58% fat, 25% protein and 17% carbohydrate, as a percentage of total kcal for two weeks15.
Hoff et al., "Fluorouracil, doxorubicin, and
streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas," Journal of Clinical Oncology, vol.
hababianum, which had shown potent in vitro antioxidant activity, had also proven to be antihyperglycemic when tested against
streptozocin induced diabetic rats [45].
Wang, "Gossypol ameliorates liver fibrosis in diabetic rats induced by high-fat diet and
streptozocin," Life Sciences, vol.
Various chemotherapeutic agents including doxorubicin,
streptozocin, cisplatin, 5-fluorouracil, and mitomycin-C alone or in combination as well as beta-emitting radioactive agents such as 90Yttrium have been used for TACE and TARE; however, there is no consensus on which therapeutic agent to use, and it remains unclear if TACE and TARE offer outcome advantage over bland embolization for this patient population [52, 54].
After one week of housing, rats were randomly divided into five groups, each consisting of eight animals; the control group that received no medication and no surgery, the model group (STZ) which received bilateral Intracerebroventricular (ICV) injection of
streptozocin (STZ, purchased from Sigma Chemical Co, St.
Table 3: Standard Chemotherapies with Known Nephrotoxicity Risk Carboplatin Cisplatin Cyclophosphamide Gemcitabine Methotrexate Mitomycin Nitrosureas Pemetrexed
Streptozocin Vinca alkaloids
Drugs used in this study was
Streptozocin (100 mg) Lyophilized powder (from Sigma Aldrich Chemicals Private Limited, Banglore) and Glimepride (1 mg) tablets (from U.S.
For induction of a human type 2 diabetes-like condition, animals in the "diabetes" and "diabetes + Zn supplementation" groups were fed with a high-fat diet for 35 days, followed by a single intraperitoneal injection (40 mg/kg) of
streptozocin (STZ).
Effect of ethanolic leaves extract on blood glucose levels of
Streptozocin induced diabetics and normoglycemic wistar rats.
