A model resembling type 2 diabetes in humans with a combination of insulin resistance and insulin deficiency was developed with administration of high fat diet consisted of 58% fat, 25% protein and 17% carbohydrate, as a percentage of total kcal7 for two weeks prior to
streptozocin injection.
Male albino wistar rats were given intraperitoneal injection of
Streptozocin to make them diabetic.
33) List Assigned number Arsenic trioxide (Trisenox[R]) P P012 Cyclophosphamide (Cytoxan[R]) U U058 Chlorambucil (Leukeran[R]) U U 035 Daunorubicin (Daunomycin[R], Cerubidine[R]) U U059 Diethylstilbestrol U U089 Melphalan (Alkeran[R]) U U150 Mitomycin (Mitomycin C[R], Mutamycin[R]) U U010
Streptozocin (Zanosar[R],
Streptozocin[R]) U U206 Uracil Mustard (Uramustine[R]) U U237 * U.
control group STZ:
Streptozocin, PDTC: Pyrrolidine dithiocarbamate
2]
Streptozocin Mitomycin Mitoxantrone Paclitaxel Moderate (30%-90% frequency Minimal (< 10% frequency of emesis) of emesis) Carboplatin Bevacizumab Cyclophosphamide < Bleomycin 1,500 mg/ [m.
Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by
streptozocin in the rat.
Melatonin protects against
streptozocin, but not interleukin-1B-induced damage of rodent pancreatic B-cells.
Examples of nitrosureas are Carmustine, Lomustine and
Streptozocin.
Combination treatment with
streptozocin and doxorubicin is the favored first-line therapy in advanced disease.
Drugs that might interfere with the results of monitoring tests Antineoplastic drugs Other drugs Azacitidine Atropine Busulfan Chloral hydrate Chlorambucil Chlordiazepoxide Cisplatin Chlorpromazine Cyclophosphamide Cimetidine Cytarabine Diazepam Dacarbazine Dobutamine Dibromodulcitol Dopamine Estramustine Ephedrine Floxuridine Fentanyl Fludarabine Haloperidol Fluorouracil Hydroxyzine Ifosfamide Meperidine Lomustine Metoclopramide Mercaptopurine Midazolam Methotrexate Morphine
Streptozocin Pentobarbital Thiopeta Phenylephrine Prochlorperazine Promethazine Ranitidine Scopolamine Secobarbital Temazepam
Chemotherapeutic agents, including cyclophosphamide, doxorubicin, 5-fluorouracil, dacarbazine, cisplatin, estramustine, and
streptozocin, alone or in combination, have produced disappointing overall response rates of approximately 30% (in those with mostly stable disease, with few complete or partial responses), with median survivals of 26 to 33 weeks.
Pre- and post-treatment of
streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism.
