streptozocin

[strep″to-zo´sin]

an antitumor antibiotic derived from Streptomyces achromogenes, now produced synthetically. It contains a nitrosourea group linked to a methyl group and a glucosamine moiety and acts as an alkylating agent to inhibit DNA synthesis, and also as an inhibitor of enzymes involved in gluconeogenesis; used primarily for treatment of islet cell carcinoma of the pancreas and other endocrine tumors including gastrinomas associated with zollinger-ellison syndrome and glucagon-secreting alpha cell tumors of the pancreas.

streptozocin

/strep·to·zo·cin/ (-zo´sin) an antineoplastic antibiotic derived from Streptomyces achromogenes; used principally in the treatment of islet cell and other tumors of the pancreas.

streptozocin

(strĕp′tə-zō′sĭn)

See streptozotocin.

streptozocin

[strep′təzō′sin]

an antineoplastic used in the treatment of neoplasms, including metastatic islet cell tumors of the pancreas. It is an antibiotic substance from Streptomyces acromogenes.

streptozocin, streptozotocin

a nitrosurea compound with antineoplastic activity, derived from Streptomyces achromogenes; used principally in the treatment of islet-cell tumors of the pancreas.

References in periodicals archive ?

A model resembling type 2 diabetes in humans with a combination of insulin resistance and insulin deficiency was developed with administration of high fat diet consisted of 58% fat, 25% protein and 17% carbohydrate, as a percentage of total kcal7 for two weeks prior to streptozocin injection.

COMPARATIVE STUDY OF TELMISARTAN WITH PIOGLITAZONE ON INSULIN RESISTANCE IN TYPE 2 DIABETIC MICE

Male albino wistar rats were given intraperitoneal injection of Streptozocin to make them diabetic.

Comparative study of aegle marmelos, azadirachta indica and glimepride on blood sugar in experimentally induced hyperglycemia in albino rats

33) List Assigned number Arsenic trioxide (Trisenox[R]) P P012 Cyclophosphamide (Cytoxan[R]) U U058 Chlorambucil (Leukeran[R]) U U 035 Daunorubicin (Daunomycin[R], Cerubidine[R]) U U059 Diethylstilbestrol U U089 Melphalan (Alkeran[R]) U U150 Mitomycin (Mitomycin C[R], Mutamycin[R]) U U010 Streptozocin (Zanosar[R], Streptozocin[R]) U U206 Uracil Mustard (Uramustine[R]) U U237 * U.

Regulations and recommendations for appropriate disposal of antineoplastics

control group STZ: Streptozocin, PDTC: Pyrrolidine dithiocarbamate

Protective effect of pyrrolidine dithiocarbamate on kidney tissue in streptozotocin-induced diabetic rats / Streptozotosin lie diyabet olusturulan sicanlarda pirolidyum dithiyokarbamat'in bobrek dokusu uzerine koruyucu etkisi

2] Streptozocin Mitomycin Mitoxantrone Paclitaxel Moderate (30%-90% frequency Minimal (< 10% frequency of emesis) of emesis) Carboplatin Bevacizumab Cyclophosphamide < Bleomycin 1,500 mg/ [m.

Comparing different antiemetic regimens for chemotherapy induced nausea and vomiting

Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat.

A multimodal approach to management of suspected neuropathic pain in a prairie falcon (Falco mexicanus)

Melatonin protects against streptozocin, but not interleukin-1B-induced damage of rodent pancreatic B-cells.

The impact of melatonin on glucose homeostasis/Melatonin ve glukoz metabolizmasi uzerine etkisi

Examples of nitrosureas are Carmustine, Lomustine and Streptozocin.

Conventional treatments: chemotherapy--a medical 'solution'

Drugs that might interfere with the results of monitoring tests Antineoplastic drugs Other drugs Azacitidine Atropine Busulfan Chloral hydrate Chlorambucil Chlordiazepoxide Cisplatin Chlorpromazine Cyclophosphamide Cimetidine Cytarabine Diazepam Dacarbazine Dobutamine Dibromodulcitol Dopamine Estramustine Ephedrine Floxuridine Fentanyl Fludarabine Haloperidol Fluorouracil Hydroxyzine Ifosfamide Meperidine Lomustine Metoclopramide Mercaptopurine Midazolam Methotrexate Morphine Streptozocin Pentobarbital Thiopeta Phenylephrine Prochlorperazine Promethazine Ranitidine Scopolamine Secobarbital Temazepam

A proposed protocol for monitoring ototoxicity in patients who take cochleo-or vestibulotoxic drugs. (Original Article)

Chemotherapeutic agents, including cyclophosphamide, doxorubicin, 5-fluorouracil, dacarbazine, cisplatin, estramustine, and streptozocin, alone or in combination, have produced disappointing overall response rates of approximately 30% (in those with mostly stable disease, with few complete or partial responses), with median survivals of 26 to 33 weeks.

Treatment of advanced prostate cancer

Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism.

Melatonin reduces cataract formation and aldose reductase activity in lenses of streptozotocin-induced diabetic rat