streptozocin


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streptozocin

 [strep″to-zo´sin]
an antitumor antibiotic derived from Streptomyces achromogenes, now produced synthetically. It contains a nitrosourea group linked to a methyl group and a glucosamine moiety and acts as an alkylating agent to inhibit DNA synthesis, and also as an inhibitor of enzymes involved in gluconeogenesis; used primarily for treatment of islet cell carcinoma of the pancreas and other endocrine tumors including gastrinomas associated with zollinger-ellison syndrome and glucagon-secreting alpha cell tumors of the pancreas.

streptozocin

(strĕp′tə-zō′sĭn)
References in periodicals archive ?
Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas.
For this study, mouse model resembling type 2 diabetes was made by giving streptozocin injection with prior administration of high fat diet consisting of 58% fat, 25% protein and 17% carbohydrate, as a percentage of total kcal for two weeks15.
Hoff et al., "Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas," Journal of Clinical Oncology, vol.
hababianum, which had shown potent in vitro antioxidant activity, had also proven to be antihyperglycemic when tested against streptozocin induced diabetic rats [45].
Wang, "Gossypol ameliorates liver fibrosis in diabetic rats induced by high-fat diet and streptozocin," Life Sciences, vol.
Various chemotherapeutic agents including doxorubicin, streptozocin, cisplatin, 5-fluorouracil, and mitomycin-C alone or in combination as well as beta-emitting radioactive agents such as 90Yttrium have been used for TACE and TARE; however, there is no consensus on which therapeutic agent to use, and it remains unclear if TACE and TARE offer outcome advantage over bland embolization for this patient population [52, 54].
After one week of housing, rats were randomly divided into five groups, each consisting of eight animals; the control group that received no medication and no surgery, the model group (STZ) which received bilateral Intracerebroventricular (ICV) injection of streptozocin (STZ, purchased from Sigma Chemical Co, St.
Table 3: Standard Chemotherapies with Known Nephrotoxicity Risk Carboplatin Cisplatin Cyclophosphamide Gemcitabine Methotrexate Mitomycin Nitrosureas Pemetrexed Streptozocin Vinca alkaloids
Drugs used in this study was Streptozocin (100 mg) Lyophilized powder (from Sigma Aldrich Chemicals Private Limited, Banglore) and Glimepride (1 mg) tablets (from U.S.
For induction of a human type 2 diabetes-like condition, animals in the "diabetes" and "diabetes + Zn supplementation" groups were fed with a high-fat diet for 35 days, followed by a single intraperitoneal injection (40 mg/kg) of streptozocin (STZ).
Effect of ethanolic leaves extract on blood glucose levels of Streptozocin induced diabetics and normoglycemic wistar rats.