streptozocin


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streptozocin

 [strep″to-zo´sin]
an antitumor antibiotic derived from Streptomyces achromogenes, now produced synthetically. It contains a nitrosourea group linked to a methyl group and a glucosamine moiety and acts as an alkylating agent to inhibit DNA synthesis, and also as an inhibitor of enzymes involved in gluconeogenesis; used primarily for treatment of islet cell carcinoma of the pancreas and other endocrine tumors including gastrinomas associated with zollinger-ellison syndrome and glucagon-secreting alpha cell tumors of the pancreas.

streptozocin

/strep·to·zo·cin/ (-zo´sin) an antineoplastic antibiotic derived from Streptomyces achromogenes; used principally in the treatment of islet cell and other tumors of the pancreas.

streptozocin

(strĕp′tə-zō′sĭn)

streptozocin

[strep′təzō′sin]
an antineoplastic used in the treatment of neoplasms, including metastatic islet cell tumors of the pancreas. It is an antibiotic substance from Streptomyces acromogenes.

streptozocin, streptozotocin

a nitrosurea compound with antineoplastic activity, derived from Streptomyces achromogenes; used principally in the treatment of islet-cell tumors of the pancreas.
References in periodicals archive ?
Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas.
Melatonin administration affects plasma total sialic acid and lipid peroxidation levels in streptozocin induced diabetic rats.
The patient received one course of streptozocin and daunorubicin and was started on mediastinal radiation therapy, which she completed approximately 1 month prior to presenting at BUMC.
She underwent radiotherapy to the spine and to painful lesions in the right humerus and left femur, and she was treated with systemic chemotherapy consisting of doxorubicin and streptozocin.
Thirty, eight week-old female Wistar rats (186 [+ or -] 12 g) were randomly assigned to two groups of healthy (n = 12) and diabetic (n = 18) induced by streptozocin injection, then healthy group were divided into two group of H1 and H2 as healthy control and diabetic group were split up into three groups of D1, D2 as diabetic control and Exe as a exercise training group.
After a week of adaptive feeding, the diabetic rat model was developed using a high-fat diet plus multiple low doses of streptozocin similar to that employed in previously studies (Wang et al.
The objective of this study was to examine the effect of chronic treatment with trimetazidine (TMZ) on cardiac mechanical function and fatty acid oxidation in streptozocin (STZ)-diabetic rats.
A sigmoidal relationship between liver stearoyi CoA desaturase activity and serum hormone concentrations caused by streptozocin and its antagooists.
2001, The mechanism of alloxan and streptozocin action in B cells of the rat pancreas.
Improving glycogenesis in streptozocin (STZ) diabetic mice after administration of green algae Chlorella.