streptomycin


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streptomycin

 [strep″to-mi´sin]
an aminoglycosideantibiotic produced by Streptomyces griseus; its use is now limited because of the emergence of resistant strains. The sulfate salt is used in combination with other agents in the treatment of tuberculosis and certain other bacterial infections.

strep·to·my·cin

(strep'tō-mī'sin),
An antibiotic agent obtained from Streptomyces griseus that is active against the tubercle bacillus and a large number of gram-positive and gram-negative bacteria; also used in the form of dihydrostreptomycin (aldehyde of streptomycin reduced to CH2OH). It is used virtually exclusively in the treatment of tuberculosis; toxicity includes eighth cranial nerve damage leading to deafness and/or vestibular dysfunction.
Synonym(s): streptomycin A

streptomycin

/strep·to·my·cin/ (-mi´sin) an aminoglycoside antibiotic produced by Streptomyces griseus and effective against a wide variety of aerobic gram-negative bacilli and some gram-positive bacteria, including mycobacteria, but to which many of the former have developed resistance; used as the sulfate salt in the treatment of tuberculosis, tularemia, plague, and brucellosis.

streptomycin

(strĕp′tə-mī′sĭn)
n.
An antibiotic, C21H39O12N7, produced by the actinomycete Streptomyces griseus, used to treat tuberculosis and other bacterial infections.

streptomycin

Infectious disease An antibiotic used for TB Adverse effects N&V, dizziness, rash, fever, ototoxicity, nephrotoxicity

strep·to·my·cin

(strep'tō-mī'sin)
Antibiotic agent obtained from Streptomyces griseus active against the tubercle bacillus and a large number of gram-positive and gram-negative bacteria; also used in the form of dihydrostreptomycin. It is used virtually exclusively in the treatment of tuberculosis; toxicity includes eighth cranial nerve damage leading to deafness and/or vestibular dysfunction. Also called streptomycin A.

streptomycin

An aminoglycoside antibiotic drug used to treat some rare infections such as BRUCELLOSIS, GLANDERS, PLAGUE, TUBERCULOSIS and TULARAEMIA. It is avoided for commoner infections because of its side effects, which include deafness and TINNITUS. The drug is on the WHO official list.

streptomycin

an ANTIBIOTIC produced by a soil ACTINOMYCETE, Streptomyces griseus, which is active against many bacteria, particularly Gram-negative bacteria (see GRAM'S STAIN). Streptomycin inhibits PROTEIN SYNTHESIS in bacteria by causing misreading of the GENETIC CODE on mRNA. It also inhibits initiation of protein synthesis by interfering with the binding of initiator tRNA to the ribosome. see TRANSLATION.

strep·to·my·cin

(strep'tō-mī'sin)
An antibiotic agent obtained from Streptomyces griseus that is active against the tubercle bacillus and many gram-positive and gram-negative bacteria; also used in the form of dihydrostreptomycin; used almost exclusively in treatment of tuberculosis; toxicity includes eighth cranial nerve damage leading to deafness or vestibular dysfunction.

streptomycin

one of the oldest of the aminoglycoside antibiotics. Because of its widespread use many previously susceptible gram-negative bacteria have developed a resistance to it and it has lost a great deal of its effectiveness and popularity. It is most effective against leptospira and haemophilus-associated infections. Like all other members of the group, streptomycin is absorbed poorly from the alimentary tract and must be given parenterally, usually by intramuscular injection for systemic effect. The group has moderate toxicity but this is of minor importance in food animals. Even in companion animals the risk is small but deafness and vestibular disturbances can occur, particularly in cats. Dihydrostreptomycin is a derivative and is used as an alternative to the parent antibiotic.
References in periodicals archive ?
Molecular analysis of Isoniazid, Rifampicin and Streptomycin Resistance in Mycobacterium tuberculosis isolates from Patients with Tuberculosis in Duzce, Turkey.
Patients who had known allergy to streptomycin or infection at the injection site or hepatic or renal impairment were excluded from the study.
These isolates were screened by PCR followed by dot blot hybridization for mutations in codon 43 and codon 88 of rpsL gene; known to be involved in streptomycin resistance (Victor et al.
faecium strains; resistance to streptomycin was detected in 76.
The values with asterisks (Fisher and Yates, 1974) are significantly different from streptomycin (a=p less than 0.
Experiment Eleven offers readers a comprehensive explanation of the scientific and legal ramifications of the streptomycin controversy as well as a window into the emotional impact the struggle had on both scientists.
The genes conferring resistance to various antibiotics (SPT) for streptomycin, (aph2, nptII or neo) for kanamycin, (aphIV=hpt) for hygromycin, [acc(3)- I] for gentamycin, G418 (aph2) for geneticin (derivative of genetamycin), (aadA) for both spectinomycin and streptomycin, (dhfr) for methotrexate resistance (Irdani et al.
Additionally, in their studies in Karachi, the primary resistance rates for the other three first line drugs in 1993 were 11%, 2%, and 9% for Isoniazid, Ethambutol and Streptomycin respectively11 which increased to 27%, 15% and 13% correspondingly in 1996.
Any drug resistance was defined as resistance to rifampin, isoniazid, pirazinamide, ethambutol, or streptomycin.
Resistance pattern of human clinical bacterial and fungal pathogens Microorganism Resistance pattern Bacterial pathogen Staphylococcus aureus MET,AML,ATM,AMC,CRO,CIP,CE, Micrococcus luteus MET,AML,FEP,STP,ATM,AMC,CRO Escherichia coli AML,FEP,STP,AMC,CRO,CE,ATM,MET Pseudomonas aeroginosa AML,STP,FEP,ATM,AMC,CRO Enterobacter STP,ATM,AMC,CRO,MET Klebsiellapneumoniae AML,STP,FEP,ATM,AMC,CRO,CE Fungal pathogen Aspergillus niger KET, MY AMC = amoxicillin/clavulanic acid; AML = amoxicillin; ATM = azteronam; CE = cephradine; CIP = ciprofloxacin; CRO = ceftrioxone; FEP = cefepime; KET = ketoconazole; MET = methicillin; MY = myconazole; STP = streptomycin Table 2.
Green Party food spokeswoman Sue Kedgley said streptomycin is used to treat Tb, urinary tract infections, and some respiratory infections, and "the spraying would inevitably lead to a build-up of resistant bacteria in the environment.