O and NAD-glycohydrolase prevent phagolysosome acidification and promote group A streptococcus survival in macrophages.
Two major cytolytic toxins are produced by Group A Streptococci (GAS), these are the oxygen-labile streptolysin
O (SLO) and the oxygen-stable streptolysin
S (SLS) .
This is based on the reactions between antibodies against streptolysin
O and the values are determined photometrically.
Tenders are invited for Anti Streptolysin
- O, Aso Kit, Latex Agglutination Kit, With Controls And Accessories, Pack Size - 100 Tests Per Pack.
Antibody titers against streptolysin
O were < 200 IU.
iniae is homologous to streptolysin
S (SLS) from GAS (21) and affects erythrocytes, neutrophils, lymphocytes, and some tissue types in tissue culture (22), but does not have roles in phagocytic resistance nor epithelial cell adherence and invasion (23).
This chromosomal region harbors genes encoding 2 important toxins, streptolysin
O (SLO) and nicotinamide glycohydrolase (NADGH or NADase), both of which were more highly expressed in M1T1-MGAS5005 compared to M1 SF370 (21).
Nonetheless, mouse antibodies to GCS/GGS M protein react with human cardiac myosin (11), and levels of antibodies to streptolysin
O and hyaluronic acid increase after infection with GCS/GGS (3).
Inmerasion oil (500 ml bottle),alcohol acid (250 ml flask),isopropyl alcohol 95% (gallon),anti streptolysin
aso (jar test),a antigen (10 ml vial) etc.
pyogenes share virulence factors such as streptokinase, C5a peptidase, M protein, streptolysin
S, and certain exotoxin genes (13-18).
Prime candidates are the streptococcal superantigens (SAgs), a family of highly mitogenic proteins secreted individually or in certain combinations by many Streptococcus pyogenes strains (7 10), although other virulence factors, such as streptolysin
O and various cell wall antigens can also cause toxic shock (11).
Characteristics of bacterial toxins(a) Organism/toxin Mode of action Damage membranes Aeromonas Pore-former hydrophila/aerolysin Clostridium Pore-former perfringens/ perfringolysin O Escherichia coli/ Pore-former hemolysin(d) Listeria monocytogenes/ Pore-former listeriolysin O Staphyloccocus aureus/ Pore-former [Alpha]-toxin Streptococcus Pore-former pneumoniae/ pneumolysin Streptococcus pyogenes/ Pore-former streptolysin
O Inhibit protein synthesis Corynebacterium ADP- diphtheriae/ ribosyltransferase diphtheria toxin E.