turevleri olan kinupristin/dalfopristin difuzyon yoluyla bakteri hucrelerine girip, sinerjistik etkiyle protein sentezinin hem erken hem de gec fazlarini durdurur (26).
A low prevalence of inducible macrolide, lincosamide, and streptogramin
b resistance phenotype among methicillin-susceptible Staphylococcus aureus isolated from malaysian patients and healthy individuals.
Antibiotic-resistant enterococci are the leading causes of hospital-acquired infections of bloodstream and urinary tract since 1980s.10 Three main reasons behind this multidrug-resistant enterococci emergence include intrinsic resistance to antimicrobial agents like beta-lactams and aminoglycosides, and acquired resistance through mobile elements like transposon and plasmids against glycopeptides, quinolones, tetracyclines, macrolides and streptogramin
or through the horizontal transfer of resistance genes.11
However, resistance to erythromycin (a macrolide) is usually associated with resistance to clindamycin (a lincosamide) and to type B streptogramin
, and this cross-resistance is normally mediated by the erythromycin ribosomal methylase (erm) genes.
Amos, "Studies directed toward the total synthesis of streptogramin
According to the results of macrolide phenotypes, the study showed that 17 strains (21.25%) have had constitutive Macrolide, Lincosamide, and Streptogramin
B (cMLSB) phenotype and eight strains (10%) have had M phenotype.
Nomenclature for macrolide and macrolide-lincosamide- streptogramin
B resistance determinants.
"Tn5406, a New Staphylococcal Transposon Conferring Resistance to Streptogramin
A and Related Compounds Including Dalfopristin.
Low, "Prevalence and characterization of the mechanisms of macrolide, lincosamide, and streptogramin
resistance in isolates of Streptococcus pneumoniae," Antimicrobial Agents and Chemotherapy, vol.
Tober, Specific Inhibition of 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells by 16-Membered Macrolide, Lincosamide, and Streptogramin
This gene mediates resistance to not only linezolid but also to phenicols, lincosamides, pleuromutilins, and streptogramin
A and macrolides3.
Pristinamycin is a streptogramin
that is used to treat vancomycin-resistant Enterococcus faecium bacteremia and complicated skin infections due to MRSA .