Comparative behaviour of Brucella abortus strain 19
and RB51 in pregnant mouse.
abortus strain 19 have been the chief defense against this devastating disease.
But the problem with using strain 19 in a vaccine has always been that it induced an antibody response, making identification of truly infected animals more difficult," says ARS veterinarian Steven C.
It's because the most common vaccine, Strain 19, uses a live strain of the brucellosis bacterium, Brucella abortus.
abortus Strain 19 to delete a specific protein immunogen, so that any animal whose blood contains that telltale protein will be known to have been naturally infected rather than vaccinated.
Antibody-mediated protection against Brucella abortus in BALB/c mice at successive periods after infection: variation between virulent strain 2308 and attenuated vaccine strain 19
But while commercial vaccines do protect cattle against brucellosis, there are significant problems with the currently used vaccine known as strain 19.
abortus vaccine strain 19 in hopes of deleting a specific protein immunogen.