storage pool disease


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storage pool

 
the area of a platelet organelle such as a dense body or an alpha granule where specific chemical constituents are stored.
storage pool disease a blood coagulation disorder due to failure of the platelets to release adenosine diphosphate (ADP) in response to aggregating agents such as collagen, epinephrine, exogenous ADP, or thrombin; characteristics include mild bleeding episodes, prolonged bleeding time, and reduced aggregation response to collagen or thrombin.

storage pool disease

inadequate number or contents of platelet delta-granules causing mucocutaneous bleeding. Storage pool disease is usually hereditary and related to oculocutaneous albinism syndromes such as Hermansky-Pudlak syndrome, Chediak-Higashi syndrome, and Wiskott-Aldrich syndrome.

storage pool disease

a blood coagulation disorder due to an abnormality in the constituents of platelet storage granules. Characterized by mild to moderate bleeding. See also thrombopathia.