storage lesion

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storage lesion

Transfusion medicine The constellation of changes occurring in a unit of packed red cells during storage. See Red cell preservatives.

Storage lesions

↑ Ammonium to 470 µmol/L–US: 800 µg/dL

↑ Free Hb in plasma from 82 to 6580 mg/L–US: 8.2 to 658 mg/dL

↑ K⁺ from 4.2 to 78.5 mmol/L–US: 4.2 to 78.5 mEq/L

↓ ATP from 100% to 45%

↓ 2,3 DPG to < 10% of original levels–replenished within 24 hours of transfusion

↓ Labile proteins, eg complement, fibronectin and coagulation factors ↓ to negligible

↓ Na⁺ from 169 to 111 mmol/L–US: 169 to 111 mEq/L

↓ pH from 7.6 to 6.7

Adverse physiologic effects of stored blood is negligible in the absence of a previous compromise of the Pt's–recipient's status

storage lesion

In blood banking and transfusion therapy, the biochemical and structural degradation of blood cells that occurs over time.

See also: lesion

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References in periodicals archive ?

They also noted a deficiency in vasodilotary activity in banked blood when compared with "fresh blood." Banked blood used for transfusion still has some shortcomings, but researchers are now contemplating reducing some of the storage lesions by replenishing nitrosylation in banked blood before using it for transfusion.

Transfusion medicine today: Mission accomplished?

These polysaccharides, called glycosaminoglycans, accumulate in tissues of MPS I patients, resulting in characteristic storage lesions and diverse clinical signs and symptoms including in the CNS.

FDA Awards Fast Track Designation to Regenxbio Gene Therapy for Treatment of MPS I

MPS I is a rare autosomal recessive genetic disease caused by deficiency of IDUA, an enzyme required for the breakdown of the polysaccharides,which accumulate in tissues of MPS I patients, resulting in characteristic storage lesions and diverse clinical signs and symptoms including in the CNS, which can include excessive accumulation of fluid in the brain, spinal cord compression and cognitive impairment, said the company.