stopping rules

in randomized controlled trials and other systematic experiments on human subjects, rules laid down in advance that specify conditions under which the experiment will be terminated, for example, unequivocal demonstration that one regimen in a randomized controlled trial is clearly superior to the other, or that one is clearly harmful.

Farlex Partner Medical Dictionary © Farlex 2012

stopping rules

A clinical trials term for statistical criteria which, when met by accumulating data, indicate that the trial should be stopped early to avoid putting participants at risk unnecessarily or because the intervention’s benefit is so great that further data collection is unnecessary.

stop·ping rules

(stop'ing rūlz)

In randomized controlled trials and other systematic experiments on human subjects, regulations set out in advance that specify conditions under which the experiment will be terminated, e.g., unequivocal demonstration that one regimen in a randomized controlled trial is clearly superior to the other, or that one is clearly harmful.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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Caption: Don't make a lake from a puddle: Here President Trump signs the Waters of the United States executive order, which directs the EPA to withdraw the expansion of the number of waterways that are federally protected under the Clean Water Act, stopping rules on puddles and ditches.

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- running a red traffic light,- unauthorized use of oncoming lane;- unauthorized use of sidewalk or bicycle path, lawns, footpaths;- running a Stop sign;- violation of rules of pedestrian crossing;- speeding;- violation of parking and stopping rules.

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Fitts (2011) pointed out the problems concerning stopping rules: Defining 0.005 as significance level in experiments with the fixed-stopping rule may lead to a considerable waste of animals in case of a very small or nonexistent hypothesized effect.

Lowering the P-Value from 0.05 to 0.005 Conflicts with the 3R Rules--an Advocacy for Alternatives to Hypothesis Testing with the P-Value Approach

In this study, no patients met predefined resistance stopping rules and 81% of patients achieved virologic suppression at Week 24 in an intent-to-treat analysis.

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No safety-related stopping rules have been met to date; none of the patients had lost the ability to swallow, required tracheostomy, or reached permanent ventilation in limited follow-up.

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But there may be a meta-preference manifesting itself in fertility stopping rules contingent on the sex of the last child, which notionally creates "unwanted" girls, estimated at about 21 million, adds the Survey.

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The Survey highlighted another phenomenon of son metapreference which involves parents adopting fertility "stopping rules" - having children until the desired number of sons are born.

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Muthulakshmi, "Stopping rules to limit inspection effort in CSP-C continuous sampling plan," International Journal of Mathematical Archive, vol.

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"There's data to suggest that we can employ early stopping rules for PSA testing in asymptomatic men," he adds.

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Recent developments of the parameter-choice methods (i.e., stopping rules) for Landweber-type methods are discussed in [24].

Vector Extrapolation Based Landweber Method for Discrete Ill-Posed Problems

"So, I think the biggest change in obesity medicine is the creation of stopping rules that allow you to say, 'OK, maybe this isn't going to work.

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That's a win-win to me, and I applaud the FDA for getting on the pharmaceutical companies to make sure they put stopping rules in their medication labels," he added.