stop codon


Also found in: Dictionary, Encyclopedia, Wikipedia.

ter·mi·na·tion co·don

trinucleotide sequence (UAA, UGA, or UAG) that specifies the end of translation or transcription. Compare: amber codon, ochre codon, umber codon.
Farlex Partner Medical Dictionary © Farlex 2012

stop codon

n.
Any of three codons, UAA, UAG, or UGA, that signal the termination of the synthesis of a protein. Also called chain termination codon, termination codon.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

stop codon

Any of the 3 codons (or triplets of nucleotides—UAA, UAG and UGA) on an mRNA molecule which lack a cognate aminoacyl tRNA—i.e., do not code for an amino acid and thus signal the end of protein synthesis. When ribosomes hit a stop codon, mRNA transcription is terminated, causing polypeptide synthesis to stop and the ribosome to dissociate from the mRNA.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

stop codon

Any one of three nucleotide triplets which marks the end of every gene and indicates that protein synthesis ends at that point. The three stop codons are UAG (the amber codon), UAA and UGA. U is uracil, A is adenine and G is guanine.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

stop codon

see NONSENSE CODON.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
This is an insertion which will cause an anticipated premature stop codon at codon 736.
(b) Compound heterozygosity with a point mutation in the second allele resulting in a stop codon, as in our patient.
The NHEJ pathway can be utilized to induce insertions and deletions for resetting an ORF containing a premature stop codon and restoring dystrophin protein expression [54].
Schuster, "GC content dependency of open reading frame prediction via stop codon frequencies" Gene, vol.
The R384X mutation creates a premature stop codon, resulting in the presence of a truncated protein without biological activity, which would have a significant burden and would be responsible for allowing the development of the pathology despite the Q356X mutation being in a heterozygous state.
NM_004484.3), causes a frameshift that results in a premature stop codon. At a protein level, this tetranucleotide deletion results in a disruption of the amino acid reading frame that causes arginine to be replaced by phenylalanine at position 358, with a resulting premature stop codon at position 373, p.(Arg358Phefs*16).
This mutation was predicted to cause premature stop codon. The clinical presentation in this study broadens the range of phenotypes associated with CDMP1 mutation in Pakistani population.
The elongation process continues until a stop codon in the mRNA is reached.
On the other hand, when the first three bases of the four-base codon are decoded as a three-base codon by a cognate naturally occurring aminoacyl-tRNA, a frame shift occurs that causes the emergence of a stop codon resulting in the termination of peptide elongation.
papaya gene, a stop codon (TAA) was identified at position 1506 to 1508 bp in VP_STK1.