Stomatocyte may also be artefactual and should be suspected when less than 10% of red cells are stomatocytes.
Non-spiculated variants include target cells, ovalocytes and stomatocytes.
Stomatocyte Haemolysis: Stomatocytes are RBCs with a defect in their membranes that causes the cells to assume a mouth or stoma-like shape.
Two of these disorders are characterised by the presence of malformed RBCs-- stomatocytes and spur cells--whereas one alcohol-related haemolytic anaemia is caused by reduced phosphate levels in the blood (i.
Moreover, microscopic examination of blood films obtained from naturally infected cases showed presence of parasite and various morphological changes in cells such as stomatocyte
, hypochromia and polychromia.
in a patient presenting with polycythemia vera.
The activity of betulinic acid and some of its analogues - betulinic aldehyde, lupeol, betulin, methyl betulinate, and betulinic acid amide has been studied on their ability (according to their hydrogen bonding properties) to cause changes in erythrocyte membrane shape towards formation of stomatocytes
WBC Toxic granulations 28 Dohle bodies 5 Vacuolations 38 Smudge cells 32 Clefted lymphocytes 10 Hairy projections 2 Auer rods 2 RBC Anisocytosis 54 Poikilocytosis 31 Microcytosis 7 Macrocytosis 2 Hypochromasia 3 Polychromasia 35 Echinocytes (burr cells) 19 Dacrocytes (teardrops) 16 Spherocytes 6 Target cells 2 Acanthocytes 1 Ovalocytes 28 Schistocytes 5 Stomatocytes
2 Howell-Jolly bodies 1 Basophilic stipplings 5 Platelet Clumped platelets 3 Platelet satellitosis 5 Large platelets 8 Giant platelets 8 Overall Cell Morphology Code Concordance, Overall Type % Concordance, % WBC Toxic granulations 78.
These include stomatocytes
, red blood cells with a comb, there are also other irreversible pathological forms of erythrocytes (Figure 4).
Marked changes in the shape of RBC from normal discocytes to echinocytes, spherocytes, stomatocytes
and acanthocytes were also observed in the blood of the rats treated with (131)I.
The abnormalities seen on the smears examined revealed the presence of nucleated red cells, basophilic stipplings, Target cells, Stomatocytes
and Tear drop cells.
Section II discusses the specifics of grading individual red blood cell abnormalities and defines a grading system described in words and images for anisocytosis, poikilocytosis, microcytosis, macrocytosis, hypochromia, polychromasia, blister cells, target cells, teardrop cells, schistocytes, sickle cells, spherocytes, acanthocytes, echinocytes, elliptocytes, stomatocytes
, Howell-Jolly bodies, basophilic stippling, Pappenheimer bodies, rouleaux, and agglutination.