Women with poor response to IVF have lowered circulating gonadotrophin surge-attenuating factor (GnSAF) bioactivity during spontaneous and stimulated cycles
. Hum Reprod.
IVM has lost its value over time because the clinical outcomes, number of matured oocytes, and developmental competence of embryos are not as good as those obtained from stimulated cycles
. Recent advances in ovarian stimulation procedures, safer protocols aimed at decreasing the risk of OHSS, have decreased the attention on IVM (16,17).
Using the Human Fertilisation and Embryology Authority database, which includes data for all IVF cycles performed in the United Kingdom from 1991 to 2012, the investigators examined 719,220 fresh IVF stimulated cycles
and 135,570 fresh IVF unstimulated cycles, resulting in 105,374 and 10,668 singleton live births, respectively.
The National Institute for Health and Clinical Excellence (Nice) recommends that couples - in which the woman is between 23 and 39 at the time of treatment and who have an identified cause for their fertility problems or who have had infertility for at least three years - should be offered up to three stimulated cycles
Analysis of the outcome of in-vitro fertilization in relation to the timing of human chorionic gonadotropin administration by the duration of estradiol rise in stimulated cycles
. Fertil Steril 1985;44:335-41.
The Nice guidance states that couples, in which the woman is aged 23 to 39 at the time of treatment and who have an identified cause for their fertility problems or who have had infertility for at least three years, should be offered up to three stimulated cycles